Protein Alignment Ugt35C1 and UGT1A7

DIOPT Version :10

• Sequence 1: NP_001097744.1
• Gene: Ugt35C1 / 53507
• FlyBaseID: FBgn0040256
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: NP_061950.2
• Gene: UGT1A7 / 54577
• HGNCID: 12539
• Length: 530
• Species: Homo sapiens
• Alignment Length: 578
• Identity: 161/578 - (27%)
• Similarity: 262/578 - (45%)
• Gaps: 123/578 - (21%)

  Fly     4 LTVIAIVFCALSAKPLESESAKILATLPFPGRSQYIFVESYLKALAAKGHQVTVI---------- 58
            |.|..::.|..      :::.|:| .:|..| |.:..::|.::.|..:||:|.|:
Human    12 LYVCLLLTCGF------AKAGKLL-VVPMDG-SHWFTMQSVVEKLILRGHEVVVVMPEVSWQLGR 68

  Fly    59 ---------NAFKNKETPNMRFIEALKAHEFAD--------EMMSLL-------------NVPLL 93
                     :.....|..:..|:      .|||        ...|||             |...|
Human    69 SLNCTVKTYSTSYTLEDQDREFM------VFADARWTAPLRSAFSLLTSSSNGIFDLFFSNCRSL 127

  Fly    94 WQQLNAMDYILNKFIDVTMEDEGVQRLLNSGETFD---LVLAEMLHMEPMYAFAQ----HFNATL 151
            :.....::|:.....|....|           .||   |::|:...: |...||:    |:
Human   128 FNDRKLVEYLKESCFDAVFLD-----------PFDACGLIVAKYFSL-PSVVFARGIFCHY---- 176

  Fly   152 VGFSSFGTDRTIDEAAGNISPISYNPLVTSPRTDRMTFLERLENHYEVIVEDIHRHFVHL-PHMR 215
                       ::|.|...:|:||.|.:....:|.|||.||:.|           |.:|| .|:.
Human   177 -----------LEEGAQCPAPLSYVPRLLLGFSDAMTFKERVWN-----------HIMHLEEHLF 219

  Fly   216 NVYKKYFPNAKKTLEEVMDS----------FSLILLGQHFSLSYPRPYLPNMIEVGGMHISHKPK 270
            ..|  :|.|..:...|::.:          .|:.||...|.|.||:|.:||||.:||:: .|:.|
Human   220 CPY--FFKNVLEIASEILQTPVTAYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGIN-CHQGK 281

  Fly   271 PLPEDIKQFIEGS-PHGVIYFSMGSNVKSKDLPQETRDTLLKTFAKLKQRVLWKFEDDDMPGKPA 334
            |:|.:.:.:|..| .||::.||:||.|  .::|::....:.....|:.|.|||::..........
Human   282 PVPMEFEAYINASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLAN 344

  Fly   335 NVLIKKWYPQPDILAHPNVKLFISHGGLLSSTESVYFGKPILGLPCFYDQHMNVQRAQRVGFGLG 399
            |.::.||.||.|:|.||..:.||:|.|.....||:..|.|::.:|.|.||..|.:|.:..|.|:.
Human   345 NTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVT 409

  Fly   400 LDLNNLKQEDLEKAIQTLLTDPSYAKASLAISERYRDQPQSAVDRAVWWTEYVIRHNGAPHLRAT 464
            |::..:..||||.|::.::.|.||.:..:.:|..::|:|...:|.||:|.|:|:||.||||||..
Human   410 LNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPA 474

  Fly   465 SRDLNFIQLNSLDTLAVILAVPLLLALLIVTLSCKLLG-----GKKQKCLHADKLKKH 517
            :.||.:.|.:|||.:..:|||.|.:|  .:|..|...|     |||.:...|.|.|.|
Human   475 AHDLTWYQYHSLDVIGFLLAVVLTVA--FITFKCCAYGYRKCLGKKGRVKKAHKSKTH 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35C1	NP_001097744.1	Glycosyltransferase_GTB-type	45..477	CDD:471961	135/490 (28%)
UGT1A7	NP_061950.2	UDPGT	26..521	CDD:278624	154/547 (28%)