Protein Alignment Ugt35C1 and UGT2B28

DIOPT Version :10

• Sequence 1: NP_001097744.1
• Gene: Ugt35C1 / 53507
• FlyBaseID: FBgn0040256
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: NP_444267.1
• Gene: UGT2B28 / 54490
• HGNCID: 13479
• Length: 529
• Species: Homo sapiens
• Alignment Length: 509
• Identity: 156/509 - (30%)
• Similarity: 253/509 - (49%)
• Gaps: 52/509 - (10%)

  Fly    36 SQYIFVESYLKALAAKGHQVTVI-NAFKNKETPNMRFIEALKAH-------EFADEMM------S 86
            |.::.:::.||.|..:||:|||: ::......||..|...|:.:       ||.:.:|      |
Human    34 SHWMNMKTILKELVQRGHEVTVLASSASILFDPNDAFTLKLEVYPTSLTKTEFENIIMQQVKRWS 98

  Fly    87 LLNVPLLWQQLNAMDYILNKFIDV-------TMEDEGVQRLLNSGETFDLVLAEMLHMEPMYAF- 143
            .:.....|...:....||.:|.|:       .:.::.|.:.|.... ||::.|:        ||
Human    99 DIQKDSFWLYFSQEQEILWEFHDIFRNFCKDVVSNKKVMKKLQESR-FDIIFAD--------AFF 154

  Fly   144 ------AQHFNATLVGFSSFGTDRTIDEAAGN-ISPISYNPLVTSPRTDRMTFLERLENHYEVIV 201
                  |...|...|....|....||:..:|. |.|.||.|:|.|..:|:|||:||::|...|:.
Human   155 PCGELLAALLNIPFVYSLCFTPGYTIERHSGGLIFPPSYIPVVMSKLSDQMTFMERVKNMIYVLY 219

  Fly   202 EDIHRHFVHLPHMRNVYKKYFPNAKKTLEEVMDSFSLILLGQHFSLSYPRPYLPNMIEVGGMHIS 266
            .|.......:......|.:.. ....||.|.|....:.|:...:|..:|.|:|||:..|||:|.
Human   220 FDFWFQMCDMKKWDQFYSEVL-GRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNIDFVGGLHC- 282

  Fly   267 HKP-KPLPEDIKQFIEGS-PHGVIYFSMGSNVKSKDLPQETRDTLLKTFAKLKQRVLWKFEDDDM 329
             || ||||:::::|::.| .:||:.||:||.:  .::..|..:.:....||:.|:|||:|:.:..
Human   283 -KPAKPLPKEMEEFVQSSGENGVVVFSLGSVI--SNMTAERANVIATALAKIPQKVLWRFDGNKP 344

  Fly   330 PGKPANVLIKKWYPQPDILAHPNVKLFISHGGLLSSTESVYFGKPILGLPCFYDQHMNVQRAQRV 394
            .....|..:.||.||.|:|..|..:.||:|||.....|::|.|.|::|:|.|:||..|:...:..
Human   345 DALGLNTRLYKWIPQNDLLGLPKTRAFITHGGANGIYEAIYHGIPMVGIPLFWDQPDNIAHMKAK 409

  Fly   395 GFGLGLDLNNLKQEDLEKAIQTLLTDPSYAKASLAISERYRDQPQSAVDRAVWWTEYVIRHNGAP 459
            |..:.||.:.:...||..|::|::.||||.:..:.:|....|||...:.|||:|.|:|:.|.||.
Human   410 GAAVRLDFHTMSSTDLLNALKTVINDPSYKENVMKLSIIQHDQPVKPLHRAVFWIEFVMCHKGAK 474

  Fly   460 HLRATSRDLNFIQLNSLDTLAVILAVPLLLALLIVTLSCKLL------GGKKQK 507
            |||..:|||.:.|.:|||.:..:||. :...:.:||..|...      .|||.|
Human   475 HLRVAARDLTWFQYHSLDVIGFLLAC-VATVIFVVTKFCLFCFWKFARKGKKGK 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35C1	NP_001097744.1	Glycosyltransferase_GTB-type	45..477	CDD:471961	144/462 (31%)
UGT2B28	NP_444267.1	UDPGT	24..525	CDD:278624	153/505 (30%)