Protein Alignment Ugt35C1 and UGT3A2

DIOPT Version :10

• Sequence 1: NP_001097744.1
• Gene: Ugt35C1 / 53507
• FlyBaseID: FBgn0040256
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: XP_011512290.1
• Gene: UGT3A2 / 167127
• HGNCID: 27266
• Length: 550
• Species: Homo sapiens
• Alignment Length: 559
• Identity: 156/559 - (27%)
• Similarity: 254/559 - (45%)
• Gaps: 86/559 - (15%)

  Fly     2 RLLTVIAIVFCALSAKPLESESAKILATLPFPGRSQYIFVESYLKALAAKGHQVTVINAFKNKET 66
            |:|.::..:...:    |.||:|||| |:...|.|.|:.::...:.|...||.||::|..:....
Human     5 RVLLLVGFLLPGV----LLSEAAKIL-TISTVGGSHYLLMDRVSQILQDHGHNVTMLNHKRGPFM 64

  Fly    67 PNM--------RF-------------IEALKAHEFADEMMSLLNVPLLWQQ--LNAMDYILNKFI 108
            |.:        |:             ::..|..|.:.:::|.| .|...|:  ..:.|:    |:
Human    65 PGLSDSPASASRYPRILYLQKYCQFGLKDFKKEEKSYQVISWL-APEDHQREFKKSFDF----FL 124

  Fly   109 DVTMEDEG-VQRLLN----------------------SGETFDLVLAEMLHMEPMYAFAQHFNAT 150
            :.|:...| .:.|||                      ..|.||:|:.|.....| :..|:.....
Human   125 EETLGGRGKFENLLNVLEYLALQCSHFLNRKDIMDSLKNENFDMVIVETFDYCP-FLIAEKLGKP 188

  Fly   151 LVGF--SSFGTDRTIDEAAGNISPISYNPLVTSPRTDRMTFLERLENHYEVIVEDIHRHFVHLPH 213
            .|..  :|||:     ...|...|:||.|:..|..||.|.|..|::| :.:......|.    .|
Human   189 FVAILSTSFGS-----LEFGLPIPLSYVPVFRSLLTDHMDFWGRVKN-FLMFFSFCRRQ----QH 243

  Fly   214 MR----NVYKKYF-PNAKKTLEEVMDSFSLILLGQHFSLSYPRPYLPNMIEVGGMHISHKP-KPL 272
            |:    |..|::| ..::..|..::....|..:...|:..:.||.|||.:.|||  :..|| ||:
Human   244 MQSTFDNTIKEHFTEGSRPVLSHLLLKAELWFINSDFAFDFARPLLPNTVYVGG--LMEKPIKPV 306

  Fly   273 PEDIKQFI-EGSPHGVIYFSMGSNVKSKDLPQETRDTLLKTFAKLKQRVLWKFEDDDMPGK---P 333
            |:|::.|| :....|.:..::||.|.:...|:..:: :...||.|.|.|:||.:....|..   .
Human   307 PQDLENFIAKFGDSGFVLVTLGSMVNTCQNPEIFKE-MNNAFAHLPQGVIWKCQCSHWPKDVHLA 370

  Fly   334 ANVLIKKWYPQPDILAHPNVKLFISHGGLLSSTESVYFGKPILGLPCFYDQHMNVQRAQRVGFGL 398
            |||.|..|.||.|:||||:::||::|||..|..|::..|.|::|:|.|.||..|:.|.:...||:
Human   371 ANVKIVDWLPQSDLLAHPSIRLFVTHGGQNSIMEAIQHGVPMVGIPLFGDQPENMVRVEAKKFGV 435

  Fly   399 GLDLNNLKQEDLEKAIQTLLTDPSYAKASLAISERYRDQPQSAVDRAVWWTEYVIRHNGAPHLRA 463
            .:.|..||.|.|...::.::.|..|..|::|.|...|..|.|...|.|.|.::|::..||.||:.
Human   436 SIQLKKLKAETLALKMKQIMEDKRYKSAAVAASVILRSHPLSPTQRLVGWIDHVLQTGGATHLKP 500

  Fly   464 TSRDLNFIQLNSLDTLAVILAVPLLLALLIVTLSCKLLG 502
            ......:.:...||....:|.    |.|..:.|..||||
Human   501 YVFQQPWHEQYLLDVFVFLLG----LTLGTLWLCGKLLG 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35C1	NP_001097744.1	Glycosyltransferase_GTB-type	45..477	CDD:471961	133/489 (27%)
UGT3A2	XP_011512290.1	Glycosyltransferase_GTB-type	23..518	CDD:471961	143/514 (28%)