Protein Alignment Ugt35C1 and UGT2A1

DIOPT Version :10

• Sequence 1: NP_001097744.1
• Gene: Ugt35C1 / 53507
• FlyBaseID: FBgn0040256
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: NP_001376494.1
• Gene: UGT2A1 / 10941
• HGNCID: 12542
• Length: 737
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 164/523 - (31%)
• Similarity: 261/523 - (49%)
• Gaps: 79/523 - (15%)

  Fly    36 SQYIFVESYLKALAAKGHQVTV--------INAFKNKETP-NMRFIEALKAHEFAD---EMMSLL 88
            |.::.::..|:.|..:.|.|||        ||:  |.::| |...|.........|   |.|.:|
Human   241 SHWLNIKIILEELIQRNHNVTVLASSATLFINS--NPDSPVNFEVIPVSYKKSNIDSLIEHMIML 303

  Fly    89 NV-----PL-LWQQLNAMDYILNKFIDVTME-DEGV-------QRLLNSGETFDLVLAE------ 133
            .:     || :|.....:..:|:.|..:.:: .:||       .||...|  ||:::|:
Human   304 WIDHRPTPLTIWAFYKELGKLLDTFFQINIQLCDGVLKNPKLMARLQKGG--FDVLVADPVTICG 366

  Fly   134 -----MLHMEPMYAFAQHFNATLVGFSSFGTDRTIDEAAGNI-SPISYNPLVTSPRTDRMTFLER 192
                 .|.:..||..            .|....|::...|.| :|:||.|...|..||:|||.||
Human   367 DLVALKLGIPFMYTL------------RFSPASTVERHCGKIPAPVSYVPAALSELTDQMTFGER 419

  Fly   193 LENHYEVIVEDIHRHFVHLPHMR--NVYKKYFPNAKKTLEEVMDSFSLILLGQHFSLSYPRPYLP 255
            ::|.....::|    ::...:..  |.|.........||.|.|....:.|:..::...:||||||
Human   420 IKNTISYSLQD----YIFQSYWGEWNSYYSKILGRPTTLCETMGKAEIWLIRTYWDFEFPRPYLP 480

  Fly   256 NMIEVGGMHISHKP-KPLPEDIKQFIEGS-PHGVIYFSMGSNVKSKDLPQETRDTLLKTFAKLKQ 318
            |...|||:|.  || ||||:::::||:.| .:||:.||:||.|  |:|.:|..:.:....|::.|
Human   481 NFEFVGGLHC--KPAKPLPKEMEEFIQSSGKNGVVVFSLGSMV--KNLTEEKANLIASALAQIPQ 541

  Fly   319 RVLWKFEDDDMPGKPA----NVLIKKWYPQPDILAHPNVKLFISHGGLLSSTESVYFGKPILGLP 379
            :|||:::..    |||    |..:..|.||.|:|.||..|.||:|||.....|::|.|.|::|:|
Human   542 KVLWRYKGK----KPATLGNNTQLFDWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHGVPMVGVP 602

  Fly   380 CFYDQHMNVQRAQRVGFGLGLDLNNLKQEDLEKAIQTLLTDPSYAKASLAISERYRDQPQSAVDR 444
            .|.||..|:...:..|..:.::||.:...||..|::|::.:|||.:.::.:|..:.|||...:||
Human   603 MFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMRLSRIHHDQPVKPLDR 667

  Fly   445 AVWWTEYVIRHNGAPHLRATSRDLNFIQLNSLDT---LAVILAVPLLLALLIVTLSCKLLG--GK 504
            ||:|.|:|:||.||.|||..:.||.:.|.:|||.   |.|.:...:.|.:.....||:..|  ||
Human   668 AVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVTTAIFLVIQCCLFSCQKFGKIGK 732

  Fly   505 KQK 507
            |:|
Human   733 KKK 735

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35C1	NP_001097744.1	Glycosyltransferase_GTB-type	45..477	CDD:471961	151/477 (32%)
UGT2A1	NP_001376494.1	UDPGT	237..725	CDD:278624	158/511 (31%)