DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and Ugt1a6a

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_659545.2	Gene:	Ugt1a6a / 94284	MGIID:	2137698	Length:	531	Species:	Mus musculus

Alignment Length:	569	Identity:	159/569 - (27%)
Similarity:	262/569 - (46%)	Gaps:	108/569 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LVLRLIVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSP--------- 61
            |||...||...||.|..:|:..|.:..|..|            |:..||:|..:.|
Mouse    18 LVLWASVLGDKLLVVPQDGSHWLSMKEIVEH------------LSERGHDIMVLVPEVNLLLGES 70

  Fly    62 -----------FPLKE------PVANIHDIPVPELFDNIEEIVGNLTNRKGTWNEFEYINQYTLG 109
                       :.|:|      ...|.|.:|...|...:.|...|:.
Mouse    71 KYYRRKIFSVTYSLEELQTRFRTFGNNHFLPGASLMGPLREYRNNMI------------------ 117

  Fly   110 LVEKVLENDGVRREILQPESLQFDLIIVDLWR---LDALYG---------LAAYFDAPIIGIASY 162
            :|:....|         .:||..|...:...|   .|||:.         ||.|.:.|.:.:..
Mouse   118 VVDMFFSN---------CQSLLKDSATLSFLRENKFDALFTDPAMPCGVILAEYLNLPSVYLFR- 172

  Fly   163 GTDWKIDELVG-NVSPLAYLQSPSF--NWFDLDTYGGRLGHFVDQSMAWINWHWRHEERHEAVYR 224
            |....::.::| :.||::|:  |.|  .:.|..|:..||.:|:...:        ....:..:|.
Mouse   173 GFPCSLEHMLGQSPSPVSYV--PRFYTKFSDHMTFPQRLANFIVNIL--------ENYLYYCLYS 227

  Fly   225 KYFPKIAD--KR--SLSEITRNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLED 285
            ||....:|  ||  ||..:.:| :|.|:...|....|||.:||:|.:||::..::.| |.|:.|.
Mouse   228 KYEIIASDLLKRDVSLPSLHQN-SLWLLRYDFVFEYPRPVMPNMIFLGGINCKKKGK-LTQEFEA 290

  Fly   286 FIQGAGEHGVIYFSLGTNVRSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWF 350
            ::..:||||::.||||:.|  ..:.:.:...:.:....:||.:||::.....|::..|.::..|.
Mouse   291 YVNASGEHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWL 353

  Fly   351 PQQDILAHPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTS 415
            ||.|:|.||..:.||||.|.....|.|..||||:.:|.|.||..|.:.::.:|.|:.||..:||:
Mouse   354 PQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTA 418

  Fly   416 DEFKDTIHQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFIT 480
            |:.::.:..::..||:.....|.:..::|:|:.|||.|::|..||:|||||||:|.|..:|.:..
Mouse   419 DDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQ 483

  Fly   481 YHSLDVLGTFLLAVWAILSIVVL----CAIKLLRAILKSKKGNISPKQK 525
            ||||||:| ||||:  :|::|.:    ||....:..  ..||.:....|
Mouse   484 YHSLDVIG-FLLAI--VLTVVFIVFKCCAYGCRKCF--GGKGRVKKSHK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	133/502 (26%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	113/458 (25%)
Ugt1a6a	NP_659545.2	egt	15..503	CDD:223071	154/541 (28%)
Ugt1a6a	NP_659545.2	UDPGT	27..522	CDD:278624	153/553 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840665
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690