DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and Ugt2b35

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001004271.1	Gene:	Ugt2b35 / 83808	RGDID:	620895	Length:	530	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	148/527 - (28%)
Similarity:	267/527 - (50%)	Gaps:	68/527 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VFPIPSHSHYYHALPYLKKLASLGHEIT----SVSPFPLKEPVANIHDIPVPELFD--NIEEIVG 88
            |:|: .:||:.:....|::|...|||:|    |.|.|...:..:::..:..|..|.  ::|....
  Rat    28 VWPM-EYSHWMNIKIILEELVQKGHEVTVLRPSASVFLDPKETSDLKFVTFPTSFSSHDLENFFT 91

  Fly    89 NLTN-------RKGTWNEFEYI-------NQYTLGLVEKVLENDGVRREILQPESLQFDLI---- 135
            ...|       |....:.|.|:       :.|.|.:.::.:.|   ::.:.:.:..:||::
  Rat    92 RFVNVWTYELPRDTCLSYFLYLQDTIDEYSDYCLTVCKEAVSN---KQFMTKLQESKFDVVFSDA 153

  Fly   136 -------IVDLWRLDALYGLAAYFDAPIIGIASYGTDWKIDELVGNVSPLAYLQSPSFNWFDLDT 193
                   |.:|.::..||.|            .:...:.|::.:|.|     |..||:.......
  Rat   154 IGPCGELIAELLQIPFLYSL------------RFSPGYTIEKYIGGV-----LFPPSYVPMIFSG 201

  Fly   194 YGGRLGHFVDQ-----SMAWINWHWR--HEERHEAVYRKYFPKIADKRSLSEITRNFALILVNQH 251
            ..|:: .|:::     .|.:.::.::  .|::.:..|.|   .:....:|:||.....:.|:..:
  Rat   202 LAGQM-TFIERVHNMICMLYFDFWFQTFREKKWDPFYSK---TLGRPTTLAEIMGKAEMWLIRSY 262

  Fly   252 FTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVRSRNLSKDRRKI 316
            :.:..|.|..||:..:||:|. :..|.||:|:|||:|.:|||||:.||||:.|  ||:::::..|
  Rat   263 WDLEFPHPISPNVDYIGGLHC-KPAKPLPKDIEDFVQSSGEHGVVVFSLGSMV--RNMTEEKANI 324

  Fly   317 LIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPNVKLFITHGGLQSTVECIHRGV 381
            :....|.:||::||:||..:...:..|..:..|.||.|:|.||..|.|:||||.....|.||.|:
  Rat   325 IAWALAQIPQKVLWRFDGKKPPTLGPNTRLYKWLPQNDLLGHPKTKAFVTHGGANGIYEAIHHGI 389

  Fly   382 PMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKRTADRYRDQP 446
            ||:|:|.|.:|..|:.|:.|:|..:.:|:|.|:..:..:.:.:::....:...|...:..:.|||
  Rat   390 PMIGIPLFGEQHDNIAHMVAKGAAVEVNFRTMSKSDMLNALEEVINNPFYKKNAMWLSTIHHDQP 454

  Fly   447 MNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLAVWAILSIVVL-CAIKLLR 510
            ..|||.|::|..:|:|||||.|:|..|.||.:..||||||:| |||...|:..::.| |.:.:.|
  Rat   455 TKPLDRAVFWIEFVMRHKGAKHLRSLGHNLPWYQYHSLDVIG-FLLTCVAVTVVLALKCFLFVYR 518

  Fly   511 AILKSKK 517
            ..:|.:|
  Rat   519 FFVKKEK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	132/488 (27%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	113/447 (25%)
Ugt2b35	NP_001004271.1	UDPGT	24..527	CDD:278624	148/527 (28%)
Ugt2b35	NP_001004271.1	egt	<270..489	CDD:223071	85/221 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344062
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690