Protein Alignment Ugt35E2 and UGT2A3

DIOPT Version :10

• Sequence 1: NP_652623.2
• Gene: Ugt35E2 / 53506
• FlyBaseID: FBgn0040255
• Length: 527
• Species: Drosophila melanogaster
• Sequence 2: XP_011530549.1
• Gene: UGT2A3 / 79799
• HGNCID: 28528
• Length: 533
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 152/547 - (27%)
• Similarity: 271/547 - (49%)
• Gaps: 68/547 - (12%)

  Fly    13 LVVALLPVLLEGARILG---VFPIPSHSHYYHALPYLKKLASLGHEITSVS-----------PFP 63
            ||..||.:...|....|   |:|. ..||:.:....|::|...|||:|.::           |..
Human     8 LVFLLLQLFCVGCGFCGKVLVWPC-DMSHWLNVKVILEELIVRGHEVTVLTHSKPSLIDYRKPSA 71

  Fly    64 LKEPVANIHDIPVPELFDNIEE------IVGNLTNRKGTWNEFEYINQY------TLGLV-EKVL 115
            ||..|  :|   :|:  |..||      :..|:.....||.....:|.:      ||.:: |..:
Human    72 LKFEV--VH---MPQ--DRTEENEIFVDLALNVLPGLSTWQSVIKLNDFFVEIRGTLKMMCESFI 129

  Fly   116 ENDGVRREILQPESLQFDLIIV-------DLWRLDALYGLAAYFDAPIIGIASYGTDWKIDELVG 173
            .|..:.:::   :...:|::::       ||        :|.....|.:..........::...|
Human   130 YNQTLMKKL---QETNYDVMLIDPVIPCGDL--------MAELLAVPFVLTLRISVGGNMERSCG 183

  Fly   174 NV-SPLAYLQSPSFNWFDLDTYGGRLGHFVDQSMAWINWHWRHEERHEAVYRKYFPK-IADKRSL 236
            .: :||:|:..|.....|..|:..|    |..||..:.:|:..::.....:.:::.| :....:|
Human   184 KLPAPLSYVPVPMTGLTDRMTFLER----VKNSMLSVLFHFWIQDYDYHFWEEFYSKALGRPTTL 244

  Fly   237 SEITRNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALP------QDLEDFIQGAGEHGV 295
            .|......:.|:..::....|:||.||...|||:|. :..||||      |::|:|:|.:||.|:
Human   245 CETVGKAEIWLIRTYWDFEFPQPYQPNFEFVGGLHC-KPAKALPKINFYLQEMENFVQSSGEDGI 308

  Fly   296 IYFSLGTNVRSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPN 360
            :.||||:  ..:|:::::..|:....|.:||::||::...:.|.:.:|..:..|.||.|:|.||.
Human   309 VVFSLGS--LFQNVTEEKANIIASALAQIPQKVLWRYKGKKPSTLGANTRLYDWIPQNDLLGHPK 371

  Fly   361 VKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQL 425
            .|.||||||:....|.|:.||||:|:|.|.||..|:.|:||:|..:.:|::.|||::....:..:
Human   372 TKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQLDNIAHMKAKGAAVEINFKTMTSEDLLRALRTV 436

  Fly   426 LTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTF 490
            :|:.|:...|.|.:..:.|||:.|||.|::|..:|:|||||.|:|.|..:|.:..::|:||:|..
Human   437 ITDSSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRSAAHDLTWFQHYSIDVIGFL 501

  Fly   491 LLAVWAILSIVVLCAIKLLRAILKSKK 517
            |..|...:.:...|.:...:...|::|
Human   502 LACVATAIFLFTKCFLFSCQKFNKTRK 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	MGT	31..443	CDD:273616	118/450 (26%)
		Glycosyltransferase_GTB-type	<247..517	CDD:471961	98/275 (36%)
UGT2A3	XP_011530549.1	UDPGT	24..528	CDD:278624	146/529 (28%)