DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E2 and UGT2A3

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	XP_011530549.1	Gene:	UGT2A3 / 79799	HGNCID:	28528	Length:	533	Species:	Homo sapiens

Alignment Length:	547	Identity:	152/547 - (27%)
Similarity:	271/547 - (49%)	Gaps:	68/547 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LVVALLPVLLEGARILG---VFPIPSHSHYYHALPYLKKLASLGHEITSVS-----------PFP 63
            ||..||.:...|....|   |:|. ..||:.:....|::|...|||:|.::           |..
Human     8 LVFLLLQLFCVGCGFCGKVLVWPC-DMSHWLNVKVILEELIVRGHEVTVLTHSKPSLIDYRKPSA 71

  Fly    64 LKEPVANIHDIPVPELFDNIEE------IVGNLTNRKGTWNEFEYINQY------TLGLV-EKVL 115
            ||..|  :|   :|:  |..||      :..|:.....||.....:|.:      ||.:: |..:
Human    72 LKFEV--VH---MPQ--DRTEENEIFVDLALNVLPGLSTWQSVIKLNDFFVEIRGTLKMMCESFI 129

  Fly   116 ENDGVRREILQPESLQFDLIIV-------DLWRLDALYGLAAYFDAPIIGIASYGTDWKIDELVG 173
            .|..:.:::   :...:|::::       ||        :|.....|.:..........::...|
Human   130 YNQTLMKKL---QETNYDVMLIDPVIPCGDL--------MAELLAVPFVLTLRISVGGNMERSCG 183

  Fly   174 NV-SPLAYLQSPSFNWFDLDTYGGRLGHFVDQSMAWINWHWRHEERHEAVYRKYFPK-IADKRSL 236
            .: :||:|:..|.....|..|:..|    |..||..:.:|:..::.....:.:::.| :....:|
Human   184 KLPAPLSYVPVPMTGLTDRMTFLER----VKNSMLSVLFHFWIQDYDYHFWEEFYSKALGRPTTL 244

  Fly   237 SEITRNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALP------QDLEDFIQGAGEHGV 295
            .|......:.|:..::....|:||.||...|||:|. :..||||      |::|:|:|.:||.|:
Human   245 CETVGKAEIWLIRTYWDFEFPQPYQPNFEFVGGLHC-KPAKALPKINFYLQEMENFVQSSGEDGI 308

  Fly   296 IYFSLGTNVRSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPN 360
            :.||||:  ..:|:::::..|:....|.:||::||::...:.|.:.:|..:..|.||.|:|.||.
Human   309 VVFSLGS--LFQNVTEEKANIIASALAQIPQKVLWRYKGKKPSTLGANTRLYDWIPQNDLLGHPK 371

  Fly   361 VKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQL 425
            .|.||||||:....|.|:.||||:|:|.|.||..|:.|:||:|..:.:|::.|||::....:..:
Human   372 TKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQLDNIAHMKAKGAAVEINFKTMTSEDLLRALRTV 436

  Fly   426 LTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTF 490
            :|:.|:...|.|.:..:.|||:.|||.|::|..:|:|||||.|:|.|..:|.:..::|:||:|..
Human   437 ITDSSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRSAAHDLTWFQHYSIDVIGFL 501

  Fly   491 LLAVWAILSIVVLCAIKLLRAILKSKK 517
            |..|...:.:...|.:...:...|::|
Human   502 LACVATAIFLFTKCFLFSCQKFNKTRK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	139/499 (28%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	120/455 (26%)
UGT2A3	XP_011530549.1	UDPGT	24..528	CDD:278624	146/529 (28%)
UGT2A3	XP_011530549.1	egt	<267..498	CDD:223071	90/233 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150226
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55988
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.690