Protein Alignment Ugt35E2 and UGT2B17

DIOPT Version :10

• Sequence 1: NP_652623.2
• Gene: Ugt35E2 / 53506
• FlyBaseID: FBgn0040255
• Length: 527
• Species: Drosophila melanogaster
• Sequence 2: NP_001068.1
• Gene: UGT2B17 / 7367
• HGNCID: 12547
• Length: 530
• Species: Homo sapiens
• Alignment Length: 515
• Identity: 139/515 - (26%)
• Similarity: 263/515 - (51%)
• Gaps: 44/515 - (8%)

  Fly    30 VFPIPSHSHYYHALPYLKKLASLGHEI------TSVSPFPLKEPVANIHDIPVPELFDNIEEIVG 88
            |:| ..:||:.:....|::|...|||:      .|:.....|.....:...|.....:::|:...
Human    28 VWP-TEYSHWINMKTILEELVQRGHEVIVLTSSASILVNASKSSAIKLEVYPTSLTKNDLEDFFM 91

  Fly    89 NLTNR------KGT-WNEFEYINQ-------YTLGLVEKVLENDGVRREILQPESLQFDLIIVD- 138
            .:.:|      |.| |:.|..:.:       |.:.|.|..:.|..:.|::   :..:||:::.|
Human    92 KMFDRWTYSISKNTFWSYFSQLQELCWEYSDYNIKLCEDAVLNKKLMRKL---QESKFDVLLADA 153

  Fly   139 ---LWRLDALYGLAAYFDAPIIGIASYGTDWKIDELVGN-VSPLAYLQSPSFNWFDLDTYGGRLG 199
               ...|     ||...:.|.:....:...:.:::..|. :.|.:|:........|...:..|:.
Human   154 VNPCGEL-----LAELLNIPFLYSLRFSVGYTVEKNGGGFLFPPSYVPVVMSELSDQMIFMERIK 213

  Fly   200 HFVDQSMAWIN-WHWRHEERHEAVYRKYFPKIADK-RSLSEITRNFALILVNQHFTMAPPRPYVP 262
            :.:  .|.:.: |...::.:.   :.:::.::..: .:|.|......:.|:..::....|||::|
Human   214 NMI--YMLYFDFWFQAYDLKK---WDQFYSEVLGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLP 273

  Fly   263 NIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVRSRNLSKDRRKILIDTFASLPQR 327
            |:..|||:|. :..|.||:::|:|:|.:||:|::.||||:.:  .|:|::...::....|.:||:
Human   274 NVDFVGGLHC-KPAKPLPKEMEEFVQSSGENGIVVFSLGSMI--SNMSEESANMIASALAQIPQK 335

  Fly   328 ILWKFDADELSDVPSNVLISPWFPQQDILAHPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQ 392
            :||:||..:.:.:.||..:..|.||.|:|.||..|.||||||.....|.|:.|:||:|:|.|.||
Human   336 VLWRFDGKKPNTLGSNTRLYKWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQ 400

  Fly   393 FRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWT 457
            ..|:.|:||:|..|.::.|.|:|.:..:.:..::.:..:.....:.:..:.|||:.|||.|::|.
Human   401 HDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVINDPIYKENIMKLSRIHHDQPVKPLDRAVFWI 465

  Fly   458 HYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLAVWAILSIVVLCAIKLLRAILKSKK 517
            .:|:|||||.|:|||..||.:|.||||||:...|..|..::.::..|.:...|.:.|:.|
Human   466 EFVMRHKGAKHLRVAAHNLTWIQYHSLDVIAFLLACVATMIFMITKCCLFCFRKLAKTGK 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	MGT	31..443	CDD:273616	105/438 (24%)
		Glycosyltransferase_GTB-type	<247..517	CDD:471961	99/269 (37%)
UGT2B17	NP_001068.1	UDPGT	24..518	CDD:278624	136/506 (27%)