DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and UGT2B15

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001067.2	Gene:	UGT2B15 / 7366	HGNCID:	12546	Length:	530	Species:	Homo sapiens

Alignment Length:	547	Identity:	152/547 - (27%)
Similarity:	276/547 - (50%)	Gaps:	65/547 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IVLVVALLPVLLEGA--RILGVFPIPSHSHYYHALPYLKKLASLGHEIT----SVSPF--PLKEP 67
            :.|::.|......|:  ::| |:| ..:||:.:....|::|...|||:|    |.|..  ..|..
Human     8 VFLLIQLSCYFSSGSCGKVL-VWP-TEYSHWINMKTILEELVQRGHEVTVLTSSASTLVNASKSS 70

  Fly    68 VANIHDIPVPELFDNIEEIVGNLTNR------KGT------------WNEFEYINQYTLGLVEKV 114
            ...:...|.....:.:|:.:..:.:|      |.|            |..::|.|:
Human    71 AIKLEVYPTSLTKNYLEDSLLKILDRWIYGVSKNTFWSYFSQLQELCWEYYDYSNK--------- 126

  Fly   115 LENDGV--RREILQPESLQFDLIIVDLWRLDALYG----LAAYFDAPIIGIASYGTDWKIDELVG 173
            |..|.|  ::.:::.:..:||:|:.     |||..    ||..|:.|.:....:...:..::..|
Human   127 LCKDAVLNKKLMMKLQESKFDVILA-----DALNPCGELLAELFNIPFLYSLRFSVGYTFEKNGG 186

  Fly   174 N-VSPLAYLQSPSFNWFDLDTYGGRLGHFVDQSMAWIN-WHWRHEERHEAVYRKYFPKIADK-RS 235
            . :.|.:|:........|...:..|:.:.:  .|.:.: |...::.:.   :.:::.::..: .:
Human   187 GFLFPPSYVPVVMSELSDQMIFMERIKNMI--HMLYFDFWFQIYDLKK---WDQFYSEVLGRPTT 246

  Fly   236 LSEITRNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSL 300
            |.|......:.|:..::....|||::||:..|||:|. :..|.||:::|:|:|.:||:|::.|||
Human   247 LFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHC-KPAKPLPKEMEEFVQSSGENGIVVFSL 310

  Fly   301 GTNVRSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPNVKLFI 365
            |:.:  .|:|::...::....|.:||::||:||..:.:.:.||..:..|.||.|:|.||..|.||
Human   311 GSMI--SNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQNDLLGHPKTKAFI 373

  Fly   366 THGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKS 430
            ||||.....|.|:.|:||:|:|.|.||..|:.|:||:|..|.::.|.|:|.:..:.:..::.:..
Human   374 THGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVINDPV 438

  Fly   431 FGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLA-- 493
            :.....:.:..:.||||.|||.|::|..:|:|||||.|:|||..||.:|.||||||: .||||
Human   439 YKENVMKLSRIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHSLDVI-AFLLACV 502

  Fly   494 ---VWAILSIVVLCAIKLLRAILKSKK 517
               ::.|....:.|..||.:...|.|:
Human   503 ATVIFIITKFCLFCFRKLAKKGKKKKR 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	134/492 (27%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	111/446 (25%)
UGT2B15	NP_001067.2	egt	8..508	CDD:223071	146/524 (28%)
UGT2B15	NP_001067.2	UDPGT	24..518	CDD:278624	145/518 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150277
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	1	0.950	-	0	Normalized mean entropy	S5046
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.640