Protein Alignment Ugt35E2 and UGT2B15

DIOPT Version :10

• Sequence 1: NP_652623.2
• Gene: Ugt35E2 / 53506
• FlyBaseID: FBgn0040255
• Length: 527
• Species: Drosophila melanogaster
• Sequence 2: NP_001067.2
• Gene: UGT2B15 / 7366
• HGNCID: 12546
• Length: 530
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 152/547 - (27%)
• Similarity: 276/547 - (50%)
• Gaps: 65/547 - (11%)

  Fly    11 IVLVVALLPVLLEGA--RILGVFPIPSHSHYYHALPYLKKLASLGHEIT----SVSPF--PLKEP 67
            :.|::.|......|:  ::| |:| ..:||:.:....|::|...|||:|    |.|..  ..|..
Human     8 VFLLIQLSCYFSSGSCGKVL-VWP-TEYSHWINMKTILEELVQRGHEVTVLTSSASTLVNASKSS 70

  Fly    68 VANIHDIPVPELFDNIEEIVGNLTNR------KGT------------WNEFEYINQYTLGLVEKV 114
            ...:...|.....:.:|:.:..:.:|      |.|            |..::|.|:
Human    71 AIKLEVYPTSLTKNYLEDSLLKILDRWIYGVSKNTFWSYFSQLQELCWEYYDYSNK--------- 126

  Fly   115 LENDGV--RREILQPESLQFDLIIVDLWRLDALYG----LAAYFDAPIIGIASYGTDWKIDELVG 173
            |..|.|  ::.:::.:..:||:|:.     |||..    ||..|:.|.:....:...:..::..|
Human   127 LCKDAVLNKKLMMKLQESKFDVILA-----DALNPCGELLAELFNIPFLYSLRFSVGYTFEKNGG 186

  Fly   174 N-VSPLAYLQSPSFNWFDLDTYGGRLGHFVDQSMAWIN-WHWRHEERHEAVYRKYFPKIADK-RS 235
            . :.|.:|:........|...:..|:.:.:  .|.:.: |...::.:.   :.:::.::..: .:
Human   187 GFLFPPSYVPVVMSELSDQMIFMERIKNMI--HMLYFDFWFQIYDLKK---WDQFYSEVLGRPTT 246

  Fly   236 LSEITRNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSL 300
            |.|......:.|:..::....|||::||:..|||:|. :..|.||:::|:|:|.:||:|::.|||
Human   247 LFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHC-KPAKPLPKEMEEFVQSSGENGIVVFSL 310

  Fly   301 GTNVRSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPNVKLFI 365
            |:.:  .|:|::...::....|.:||::||:||..:.:.:.||..:..|.||.|:|.||..|.||
Human   311 GSMI--SNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQNDLLGHPKTKAFI 373

  Fly   366 THGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKS 430
            ||||.....|.|:.|:||:|:|.|.||..|:.|:||:|..|.::.|.|:|.:..:.:..::.:..
Human   374 THGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVINDPV 438

  Fly   431 FGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLA-- 493
            :.....:.:..:.||||.|||.|::|..:|:|||||.|:|||..||.:|.||||||: .||||
Human   439 YKENVMKLSRIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHSLDVI-AFLLACV 502

  Fly   494 ---VWAILSIVVLCAIKLLRAILKSKK 517
               ::.|....:.|..||.:...|.|:
Human   503 ATVIFIITKFCLFCFRKLAKKGKKKKR 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	MGT	31..443	CDD:273616	109/444 (25%)
		Glycosyltransferase_GTB-type	<247..517	CDD:471961	104/274 (38%)
UGT2B15	NP_001067.2	UDPGT	24..518	CDD:278624	145/518 (28%)