Protein Alignment Ugt35E2 and UGT2B4

DIOPT Version :9

• Sequence 1: NP_652623.2
• Gene: Ugt35E2 / 53506
• FlyBaseID: FBgn0040255
• Length: 527
• Species: Drosophila melanogaster
• Sequence 2: NP_066962.2
• Gene: UGT2B4 / 7363
• HGNCID: 12553
• Length: 528
• Species: Homo sapiens
• Alignment Length: 525
• Identity: 148/525 - (28%)
• Similarity: 259/525 - (49%)
• Gaps: 76/525 - (14%)

  Fly    37 SHYYHALPYLKKLASLGHEIT------SVSPFPLKEPVANIHDIPVPELFDNIEEIVGNLTNRKG 95
            ||:.:....|.:|...|||:|      |:|..|...........||.......|:|:..|..|
Human    34 SHWMNIKTILDELVQRGHEVTVLASSASISFDPNSPSTLKFEVYPVSLTKTEFEDIIKQLVKR-- 96

  Fly    96 TWNE------FEYINQYTLGLVEKVL--ENDGVR---REILQPESL-------QFDLIIVDLWRL 142
             |.|      :.|.:|     |::::  .||.:|   ::|:..:.|       :||:::.
Human    97 -WAELPKDTFWSYFSQ-----VQEIMWTFNDILRKFCKDIVSNKKLMKKLQESRFDVVLA----- 150

  Fly   143 DALYG----LAAYFDAPIIGIASYGTDWKIDELVGN-VSPLAYLQSPSFNWFDLDTYGGRLGHFV 202
            ||::.    ||.....|.:....:...:.|::..|. :.|.:|:........|..|:..|:
Human   151 DAVFPFGELLAELLKIPFVYSLRFSPGYAIEKHSGGLLFPPSYVPVVMSELSDQMTFIERV---- 211

  Fly   203 DQSMAWINWHWRHEERHEAVYRKYFPKIADKR--------------SLSEITRNFALILVNQHFT 253
             ::|.::            :|.:::.:|.|.:              :|||......:.|:..::.
Human   212 -KNMIYV------------LYFEFWFQIFDMKKWDQFYSEVLGRPTTLSETMAKADIWLIRNYWD 263

  Fly   254 MAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVRSRNLSKDRRKILI 318
            ...|.|.:||:..|||:|. :..|.||:::|:|:|.:||:||:.||||:.|  .|.|::|..::.
Human   264 FQFPHPLLPNVEFVGGLHC-KPAKPLPKEMEEFVQSSGENGVVVFSLGSMV--SNTSEERANVIA 325

  Fly   319 DTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPNVKLFITHGGLQSTVECIHRGVPM 383
            ...|.:||::||:||.::...:..|..:..|.||.|:|.||..:.||||||.....|.|:.|:||
Human   326 SALAKIPQKVLWRFDGNKPDTLGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPM 390

  Fly   384 LGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKRTADRYRDQPMN 448
            :|:|.|.||..|:.|:||:|..:.|::..|:|.:..:.:..::.:..:...|.:.:..:.|||:.
Human   391 VGVPLFADQPDNIAHMKAKGAAVSLDFHTMSSTDLLNALKTVINDPLYKENAMKLSRIHHDQPVK 455

  Fly   449 PLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLAVWAILSIVVLCAIKLLRAIL 513
            |||.|::|..:|:|||||.|:|||..:|.:..||||||.|..|..|..::.|:..|...:.:.:.
Human   456 PLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVTGFLLACVATVIFIITKCLFCVWKFVR 520

  Fly   514 KSKKG 518
            ..|||
Human   521 TGKKG 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	134/486 (28%)
		YjiC	26..440	CDD:224732	115/445 (26%)
UGT2B4	NP_066962.2	egt	8..512	CDD:223071	144/510 (28%)
		UDPGT	24..524	CDD:278624	145/522 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150428
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690