DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E2 and ugt5a1

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001032497.2	Gene:	ugt5a1 / 641479	ZFINID:	ZDB-GENE-051120-60	Length:	525	Species:	Danio rerio

Alignment Length:	531	Identity:	155/531 - (29%)
Similarity:	263/531 - (49%)	Gaps:	61/531 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ALLPVL--LEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSP---FPLKEPVANIHDIP 75
            :||.||  ..|.::| |||:.. ||:.:....:::|...||.:|.|.|   :.:||.......|.
Zfish    11 SLLCVLSGTYGGKVL-VFPLDG-SHWVNMKVLIEELHRKGHNVTVVRPSNSWYIKEESPFYSSIT 73

  Fly    76 VPEL--FDNIEEIVGNLTNR-----KGTW-------NEFEYINQY------TLGLVEKVLENDGV 120
            :|..  ||  ||..|.|.||     :|.:       .|||.:.::      .|.:::::||::.|
Zfish    74 IPNTGGFD--EEFSGLLINRLLEIKRGGYFVLNRVRLEFEIMMKFKTMHEDMLQMMDRMLEDEKV 136

  Fly   121 RREILQPESLQFDLIIVDLWRLDALYG---LAAYFDAPIIGIASYGTDWKID---ELVGNVSPLA 179
            ...|   :..:||:::.|    .|:.|   ||..|:.|::    :...|.|.   ......|||:
Zfish   137 MNSI---QDAKFDVVLAD----PAVGGGPILAYKFNIPLV----FNVRWTIQGEGHFAIAPSPLS 190

  Fly   180 YLQSPSFNWFDLDTYGGRLGHFVDQSMAWINWHWRHEERHEAVYRKYF-PKIADKRSLSEITRNF 243
            |:..|.....|..::..|:.:.:...::.|......|..:.....|:| |.:    :...:.::.
Zfish   191 YIPVPGVELTDKMSFLQRVKNVLIYLISQIQMQIMVEPIYAPFCHKHFGPNV----TYFSLFQDA 251

  Fly   244 ALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVRSRN 308
            .:.|:...||...|||.:|||:.:.|... :..|.||.|||.|::.:||||||..||||.:  ..
Zfish   252 DIWLMRNDFTFEFPRPTMPNIVYMSGFQC-KPAKPLPNDLEKFVESSGEHGVIVMSLGTLI--AQ 313

  Fly   309 LSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPNVKLFITHGGLQST 373
            |.:|....:...||.|||:::|::.......:.:|.|:..|.||.|:|.||.:|:|:.|||....
Zfish   314 LPQDMTDDIAAAFAELPQKVIWRYTGPRPVTLGNNTLLVEWLPQNDLLGHPQIKVFVAHGGTNGI 378

  Fly   374 VECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKRT 438
            .|.|:.|||:||||..:||..|:..::|:|...:::...:....|.:.:.::|...|:....:|.
Zfish   379 QEAIYHGVPILGLPLVFDQPDNLFRMEAKGTAKIVDIATLDKTVFLEALKEVLYNPSYRENMQRL 443

  Fly   439 ADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGT-------FLLAVWA 496
            :..:.|||:.|||.|::|..:|:|:|||||:|.....:.:|.|||:||:.|       |.|.:..
Zfish   444 SKLHHDQPLKPLDRAMFWIEFVMRNKGAPHLRTQSFRMSWIEYHSIDVILTLMVTGFVFALMIGY 508

  Fly   497 ILSIVVLCAIK 507
            .:....||..:
Zfish   509 TIKYFCLCVFR 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	141/487 (29%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	123/443 (28%)
ugt5a1	NP_001032497.2	UDPGT	22..525	CDD:278624	150/520 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584428
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.690