Protein Alignment Ugt35E2 and Ugt1a8

DIOPT Version :10

• Sequence 1: NP_652623.2
• Gene: Ugt35E2 / 53506
• FlyBaseID: FBgn0040255
• Length: 527
• Species: Drosophila melanogaster
• Sequence 2: NP_001365304.1
• Gene: Ugt1a8 / 613123
• MGIID: 3576090
• Length: 530
• Species: Mus musculus
• Alignment Length: 556
• Identity: 153/556 - (27%)
• Similarity: 269/556 - (48%)
• Gaps: 75/556 - (13%)

  Fly     6 LVLRLIVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSP--------- 61
            |.||:.:|   |...|.:..|:| |.|:.. ||::.....::||:..|||:..|.|
Mouse    10 LPLRVCLL---LAFGLAQAGRLL-VVPMDG-SHWFSMKMIVEKLSHRGHEVVVVIPEVSWHLGKS 69

  Fly    62 --FPLK--------EPVANIHDIPVPELFDNIEEIVGNLTNRKGTWNEFEYINQYTLGLVEKVLE 116
              |.:|        |.:::..:....:.::|.|..:.:|....|. ..|:.:..:.     :.|.
Mouse    70 QNFTVKTYSVSYTLEDLSHHFNFFAHKQWENREVGMFSLLKHSGK-GFFQVLFSHC-----RSLF 128

  Fly   117 NDGVRREILQPESLQFDLIIVDLWRLDALYGLAAYFDAPII----GIASYGTDWKIDELVGNVSP 177
            ||....|.|:..|  ||.:.:|.:.:..| .:|.||..|.:    ||..:    .:||.....||
Mouse   129 NDKKLVEYLKQRS--FDAVFLDPFDVCGL-TIAKYFSLPSVVFSGGIFCH----YLDEGAQCPSP 186

  Fly   178 LAYLQSPSFNWFDLDTYGGRLGHFVDQSMAWINWHWRHEERHEAVYRKYFPKIA---------DK 233
            .:|:......:.|..|:..|:            |:: .....|..:..||.|.|         ..
Mouse   187 PSYVPRILSKFADTMTFKERV------------WNY-FSYMKERAFCPYFFKTAIEIASEVLQTP 238

  Fly   234 RSLSEITRNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYF 298
            .:::::..:.::.:....|.:..|||.:||::.:||::. ...|.|.::.|.::..:||||::.|
Mouse   239 VTMTDLFSSVSIWMFRTDFVLEFPRPVMPNMVYIGGINC-HPGKPLSKEFEAYVNASGEHGIVVF 302

  Fly   299 SLGTNVRSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPNVKL 363
            |||:.|  ..:.:.:...:.:....:||.:||::.....|::..|.::..|.||.|:|.||..:.
Mouse   303 SLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRA 365

  Fly   364 FITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTE 428
            ||||.|.....|.|..||||:.:|.|.||..|.:.::.:|.|:.||..:||:|:.::.:..::..
Mouse   366 FITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINN 430

  Fly   429 KSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLA 493
            ||:.....|.:..::|:|:.|||.|::|..||:|||||||:|.|..:|.:..||||||:| ||||
Mouse   431 KSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIG-FLLA 494

  Fly   494 VWAILSIVVL----CAIKLLRAILKSKKGNISPKQK 525
            :  :|::|.:    ||....:..  ..||.:....|
Mouse   495 I--VLTVVFIVFKCCAYGCRKCF--GGKGRVKKSHK 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	MGT	31..443	CDD:273616	107/443 (24%)
		Glycosyltransferase_GTB-type	<247..517	CDD:471961	93/273 (34%)
Ugt1a8	NP_001365304.1	UDPGT	26..521	CDD:278624	146/530 (28%)