DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and Ugt1a8

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001365304.1	Gene:	Ugt1a8 / 613123	MGIID:	3576090	Length:	530	Species:	Mus musculus

Alignment Length:	556	Identity:	153/556 - (27%)
Similarity:	269/556 - (48%)	Gaps:	75/556 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LVLRLIVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSP--------- 61
            |.||:.:|   |...|.:..|:| |.|:.. ||::.....::||:..|||:..|.|
Mouse    10 LPLRVCLL---LAFGLAQAGRLL-VVPMDG-SHWFSMKMIVEKLSHRGHEVVVVIPEVSWHLGKS 69

  Fly    62 --FPLK--------EPVANIHDIPVPELFDNIEEIVGNLTNRKGTWNEFEYINQYTLGLVEKVLE 116
              |.:|        |.:::..:....:.::|.|..:.:|....|. ..|:.:..:.     :.|.
Mouse    70 QNFTVKTYSVSYTLEDLSHHFNFFAHKQWENREVGMFSLLKHSGK-GFFQVLFSHC-----RSLF 128

  Fly   117 NDGVRREILQPESLQFDLIIVDLWRLDALYGLAAYFDAPII----GIASYGTDWKIDELVGNVSP 177
            ||....|.|:..|  ||.:.:|.:.:..| .:|.||..|.:    ||..:    .:||.....||
Mouse   129 NDKKLVEYLKQRS--FDAVFLDPFDVCGL-TIAKYFSLPSVVFSGGIFCH----YLDEGAQCPSP 186

  Fly   178 LAYLQSPSFNWFDLDTYGGRLGHFVDQSMAWINWHWRHEERHEAVYRKYFPKIA---------DK 233
            .:|:......:.|..|:..|:            |:: .....|..:..||.|.|         ..
Mouse   187 PSYVPRILSKFADTMTFKERV------------WNY-FSYMKERAFCPYFFKTAIEIASEVLQTP 238

  Fly   234 RSLSEITRNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYF 298
            .:::::..:.::.:....|.:..|||.:||::.:||::. ...|.|.::.|.::..:||||::.|
Mouse   239 VTMTDLFSSVSIWMFRTDFVLEFPRPVMPNMVYIGGINC-HPGKPLSKEFEAYVNASGEHGIVVF 302

  Fly   299 SLGTNVRSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPNVKL 363
            |||:.|  ..:.:.:...:.:....:||.:||::.....|::..|.::..|.||.|:|.||..:.
Mouse   303 SLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRA 365

  Fly   364 FITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTE 428
            ||||.|.....|.|..||||:.:|.|.||..|.:.::.:|.|:.||..:||:|:.::.:..::..
Mouse   366 FITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINN 430

  Fly   429 KSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLA 493
            ||:.....|.:..::|:|:.|||.|::|..||:|||||||:|.|..:|.:..||||||:| ||||
Mouse   431 KSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIG-FLLA 494

  Fly   494 VWAILSIVVL----CAIKLLRAILKSKKGNISPKQK 525
            :  :|::|.:    ||....:..  ..||.:....|
Mouse   495 I--VLTVVFIVFKCCAYGCRKCF--GGKGRVKKSHK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	129/489 (26%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	110/445 (25%)
Ugt1a8	NP_001365304.1	UDPGT	26..521	CDD:278624	146/530 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840330
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690