DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and UGT2A2

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001099147.2	Gene:	UGT2A2 / 574537	HGNCID:	28183	Length:	536	Species:	Homo sapiens

Alignment Length:	557	Identity:	159/557 - (28%)
Similarity:	278/557 - (49%)	Gaps:	63/557 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPMSMLVLRLIVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEIT----SVSP 61
            ||...  ::::|..:.|..|:|.| .:| ::|... ||:.:....|::|....|.:|    |.:.
Human     9 MPKKF--VQMLVFNLTLTEVVLSG-NVL-IWPTDG-SHWLNIKIILEELIQRNHNVTVLASSATL 68

  Fly    62 FPLKEP--VANIHDIPVPELFDNIEEIVGNL----TNRKGT----WNEFEYIN-------QYTLG 109
            |....|  ..|...|||.....||:.::.::    .:.:.|    |..::.:.       |..:.
Human    69 FINSNPDSPVNFEVIPVSYKKSNIDSLIEHMIMLWIDHRPTPLTIWAFYKELGKLLDTFFQINIQ 133

  Fly   110 LVEKVLENDGVRREILQPESLQFDLIIVDLWRL--DALYGLAAYFDAPIIGIASYGTDWKIDELV 172
            |.:.||:|..:...:   :...||:::.|...:  |.   :|.....|.:....:.....::...
Human   134 LCDGVLKNPKLMARL---QKGGFDVLVADPVTICGDL---VALKLGIPFMYTLRFSPASTVERHC 192

  Fly   173 GNV-SPLAYLQSPSFNWFDLDTYGGRLGHFVDQSMA-------WINWHWRHEERHEAVYRKYFPK 229
            |.: :|::|:.:......|..|:|.|:.:.:..|:.       |..|:            .|:.|
Human   193 GKIPAPVSYVPAALSELTDQMTFGERIKNTISYSLQDYIFQSYWGEWN------------SYYSK 245

  Fly   230 IADK-RSLSEITRNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEH 293
            |..: .:|.|......:.|:..::....||||:||...|||:|. :..|.||:::|:|||.:|::
Human   246 ILGRPTTLCETMGKAEIWLIRTYWDFEFPRPYLPNFEFVGGLHC-KPAKPLPKEMEEFIQSSGKN 309

  Fly   294 GVIYFSLGTNVRSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAH 358
            ||:.||||:.|  :||::::..::....|.:||::||::...:.:.:.:|..:..|.||.|:|.|
Human   310 GVVVFSLGSMV--KNLTEEKANLIASALAQIPQKVLWRYKGKKPATLGNNTQLFDWIPQNDLLGH 372

  Fly   359 PNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIH 423
            |..|.||||||.....|.|:.||||:|:|.|.||..|:.|:||:|..:.:|...|||.:....:.
Human   373 PKTKAFITHGGTNGIYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALR 437

  Fly   424 QLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLG 488
            .::.|.|:...|.|.:..:.|||:.|||.|::|..:|:|||||.|:|||..:|.:..||||||:|
Human   438 TVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIG 502

  Fly   489 TFLLAVWAILSIVVLCAIKLLRAILKSKKGNISPKQK 525
            ..|:.|...:.:|:.|.:     ....|.|.|..|:|
Human   503 FLLVCVTTAIFLVIQCCL-----FSCQKFGKIGKKKK 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	137/489 (28%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	117/445 (26%)
UGT2A2	NP_001099147.2	UDPGT	30..524	CDD:278624	148/522 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150172
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.690