DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E2 and Ugt1a5

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001034638.1	Gene:	Ugt1a5 / 574523	RGDID:	1583689	Length:	531	Species:	Rattus norvegicus

Alignment Length:	540	Identity:	152/540 - (28%)
Similarity:	269/540 - (49%)	Gaps:	50/540 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSP----FPLKEPVANI 71
            ::|::..|| ..||.::| |||:.. ||:......:::|.:.||:...::|    ...:|....:
  Rat    13 LLLLLYALP-WAEGGKVL-VFPMEG-SHWLSMRDVVRELHARGHQAVVLAPEVTVHIKEEDFFTL 74

  Fly    72 HDIPVP--------ELFDNIEEIVGNLTNRKGTWNE----FEYINQYTLGLVEKVLENDGVRREI 124
            ...|||        ::..|| ::|....|...|:.|    .:.|:...|.....:|.|..:.:.:
  Rat    75 QTYPVPYTRQGFRQQMMRNI-KVVFETGNYVKTFLETSEILKNISTVLLRSCMNLLHNGSLLQHL 138

  Fly   125 LQPESLQFDLIIVD-LWRLDALYGLAAYFDAPIIGIASY---GTDWKIDELVGNVSPLAYLQSPS 185
               .|..||:::.| :....|:  ||.|...|.:....|   |.|   .|......|.:|:.:..
  Rat   139 ---NSSSFDMVLTDPVIPCGAV--LAKYLGIPTVFFLRYIPCGID---SEATQCPKPSSYIPNLL 195

  Fly   186 FNWFDLDTYGGRLGHFVDQSMAWINWHWRHEERHEAVYRKYFPKIADKRSLSEITRNFALILVNQ 250
            ....|..|:..|:.:.:.........|:.. .|:|::..:...:   :.||.|:..:.::.|...
  Rat   196 TMLSDHMTFLQRVKNMLYPLALKYICHFSF-TRYESLASELLQR---EVSLVEVLSHASVWLFRG 256

  Fly   251 HFTMAPPRPYVPNIIEVGGMH-VDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVRSRNLSKDRR 314
            .|....|||.:||::.:||:: |.::|  |.|:.|.::..:||||::.||||:.|  ..:.:.:.
  Rat   257 DFVFDYPRPVMPNMVFIGGINCVIKKP--LSQEFEAYVNASGEHGIVVFSLGSMV--SEIPEKKA 317

  Fly   315 KILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPNVKLFITHGGLQSTVECIHR 379
            ..:.:....:||.:||::.....|::..|.::..|.||.|:|.||..:.||||.|.....|.|..
  Rat   318 MEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICN 382

  Fly   380 GVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKRTADRYRD 444
            ||||:.:|.|.||..|.:.::.:|.|:.||..:||:|:.::.:..::..||:.....|.:..::|
  Rat   383 GVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKD 447

  Fly   445 QPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLAVWAILSIVVL----CA 505
            :|:.|||.|::|..||:|||||||:|.|..:|.:..||||||:| ||||:  :|::|.:    ||
  Rat   448 RPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIG-FLLAI--VLTVVFIVYKSCA 509

  Fly   506 IKLLRAILKSKKGNISPKQK 525
            ....:..  ..||.:....|
  Rat   510 YGCRKCF--GGKGRVKKSHK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	131/478 (27%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	110/434 (25%)
Ugt1a5	NP_001034638.1	UDPGT	26..522	CDD:278624	146/519 (28%)
Ugt1a5	NP_001034638.1	egt	<259..505	CDD:223071	92/252 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344037
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.790