DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E2 and ugt5c3

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001122186.1	Gene:	ugt5c3 / 563413	ZFINID:	ZDB-GENE-050419-23	Length:	531	Species:	Danio rerio

Alignment Length:	532	Identity:	145/532 - (27%)
Similarity:	268/532 - (50%)	Gaps:	56/532 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LIVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHE---ITSVSPFPLKEPVANI 71
            |.:.::.|...|.:|.:|| |.|:.. ||:.:....:|.|...||.   |.:.:.:.:||.....
Zfish    13 LWITIIPLFGFLCDGGKIL-VVPLEG-SHWLNMDILIKALHGKGHSIDVIRNTNSWYVKEKSDYY 75

  Fly    72 HDIPVPELFDNIEEIVGNLTNR-------KGTW------------NEFEYINQYTLGLVEKVLEN 117
            :.|.:|:.....||.|.::.::       |.:|            :.:| :.:....:...:.|:
Zfish    76 NSITIPQSKGMDEEFVDDMISKVINHERGKSSWLSTVKLFFDSVIDNYE-MTKMVCDITTSIFES 139

  Fly   118 DGVRREILQP-ESLQFDLIIVD-LWRLDALYGLAAYFDAPIIGIASYGTDW--KIDELVGNV--- 175
            :    |||:. :..|:||::.| :|.:..:  ||.....|::    |...|  .:|   |:.
Zfish   140 E----EILKTLQEKQYDLMLTDPVWGMGII--LAHKLKLPMV----YNVRWTTTVD---GHFNIA 191

  Fly   176 -SPLAYLQSPSFNWFDLDTYGGRLGHFVDQSMAWINWHWRHEERHEAVYRKYFPKIADKRSLSEI 239
             ||::|:........|..::..|:.:.:......|.:......:::|:..|||....|   ..::
Zfish   192 PSPMSYIPITGSGNTDRMSFFQRVKNIIFYFTNDIKYSRFSLPQYQAICDKYFDPPVD---FYQL 253

  Fly   240 TRNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNV 304
            .:...:.|:...|....|||.:||||..||... ...|.||.|||||:|.:|:||||..||||.:
Zfish   254 LQGADIWLMRVDFVFEFPRPTMPNIIYTGGFQC-TPAKPLPHDLEDFMQSSGDHGVIVMSLGTFI 317

  Fly   305 RSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPNVKLFITHGG 369
            .:  |.:|....:...||.|||:::|::...:.|.:.:|.|:..|.||:|:|.||..|:|:.|||
Zfish   318 SA--LPEDVTAEIAAAFARLPQKVIWRYTGKKPSTLGNNTLLVDWMPQKDLLGHPKTKVFVAHGG 380

  Fly   370 LQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVK 434
            .....|.::.|||::|:|||:||:.|:..::|:|...:::..::..:.....|.:::...|:.:.
Zfish   381 TNGVQEALYHGVPVVGIPFFFDQYDNLIRLQARGGAKIVSLAELGENSLHAAIKEVINNPSYRLT 445

  Fly   435 AKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDV----LGTFLLAVW 495
            .::.:..:.|:|:.|||:||:|..:|:|||||.|:|.....:.:.:|||:||    :...|:.::
Zfish   446 MQKLSQLHLDKPVKPLDSAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVAVTLIAVVLIFIF 510

  Fly   496 AILSIVVLCAIK 507
            :|..:|....||
Zfish   511 SIFYVVRYVCIK 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	132/487 (27%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	115/443 (26%)
ugt5c3	NP_001122186.1	UDPGT	28..530	CDD:278624	141/517 (27%)
ugt5c3	NP_001122186.1	egt	<267..507	CDD:223071	86/242 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585077
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.690