DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and ugt5g2

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001186305.1	Gene:	ugt5g2 / 556049	ZFINID:	ZDB-GENE-081028-66	Length:	534	Species:	Danio rerio

Alignment Length:	565	Identity:	159/565 - (28%)
Similarity:	267/565 - (47%)	Gaps:	91/565 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LRLIVLVVALLPVLLEG---ARILGVFPIPSHSHYYHALPYLKKLASLGHEITSV---------- 59
            :.|:.|..:||..|..|   .:|| ||||.. ||:.:....:|||.|.|||::.:
Zfish     5 MSLVFLWTSLLLSLPSGYNADKIL-VFPIDG-SHWVNMEVLVKKLQSRGHELSVIRLEDSWFIKG 67

  Fly    60 -SPF------PLKEPVANI--------------HDIPVPELFDNIEEIVGNLTNRKGTWNEFEYI 103
             ||:      .||:...::              .|.|:..:...:.|.:|.|....|.
Zfish    68 NSPYYSSITVTLKKKFIDLDLFETAVKKILDARRDGPIMGVLAQMSEFIGILKVGHGA------- 125

  Fly   104 NQYTLGLVEKVLENDGVRREILQPESLQFDLIIVDLWRLDALYG---LAAYFDAPIIGIASYGTD 165
               .:.::..:|||..:..:|   :...:||::.|    .|:.|   ||.|...|::    |...
Zfish   126 ---NIAMLTSMLENKVLMSQI---KMANYDLMLTD----PAMPGGVILAHYLHLPMV----YNVR 176

  Fly   166 W-KIDELVGNV----SPLAYLQSPSFNWFDLDTYGGRLG------HFVDQSMAWINWHWRHEERH 219
            | ...|  |:.    ||::::..|.....|      |:|      :|:...:..|...|.....:
Zfish   177 WMSFGE--GHFSIAPSPISFVPVPGSGLTD------RMGLLERSRNFLHYGLNLIQERWMVIPMY 233

  Fly   220 EAVYRKYFPKIADKRSLSEITRNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLE 284
            .::...:||...|   |..:.|:..|.||...|....|||.:||::.:||... :..|.||.|||
Zfish   234 TSLLLNHFPPGTD---LLTMQRSAELWLVRADFVFEFPRPSMPNLVYIGGFQC-RPAKPLPADLE 294

  Fly   285 DFIQGAGEHGVIYFSLGTNVRSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPW 349
            :|:|.:|:|||:..||||.:  ..|.|:..:.:...||.:||:::|:|.....|.:.:|.|:..|
Zfish   295 EFMQSSGDHGVVVMSLGTLI--AGLPKEVMEAIASAFAQIPQKVIWRFIGQRPSTLGNNTLLIQW 357

  Fly   350 FPQQDILAHPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMT 414
            .||.|:|.||..:.|:.|||.....|.|:.|||:||||..:||..|:..::|:|...:|:....:
Zfish   358 LPQNDLLGHPKTRAFVAHGGTNGLYEAIYHGVPVLGLPLLFDQLDNIVRLQARGGARMLDAATCS 422

  Fly   415 SDEFKDTIHQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFI 479
            :.||...:..:|...::....::.::.:||:|::|||.|::|..:|||:|||||:|....|:...
Zfish   423 TKEFLVALTDILENPTYRQNMQKLSNLHRDRPLHPLDKAVYWIEFVLRNKGAPHLRAEAYNVSEF 487

  Fly   480 TYHSLDVLGTFLLAVWAIL-SIVVLCAIKLLRAILK-----SKKG 518
            :|:.|||:...|..:...| .:..:|..:..|...|     :|||
Zfish   488 SYYCLDVVALVLFMLLGTLGGVYTICKRRPKRQENKTGGDWNKKG 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	142/505 (28%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	123/458 (27%)
ugt5g2	NP_001186305.1	egt	3..507	CDD:223071	152/538 (28%)
ugt5g2	NP_001186305.1	UDPGT	25..513	CDD:278624	147/524 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584620
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.690