DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and ugt2a2

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001018306.2	Gene:	ugt2a2 / 553952	ZFINID:	ZDB-GENE-080721-21	Length:	534	Species:	Danio rerio

Alignment Length:	580	Identity:	152/580 - (26%)
Similarity:	255/580 - (43%)	Gaps:	105/580 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MSMLVLRLIVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEIT----SVSP-- 61
            |...:|:...||:..:........:| |.| ..:||:.:....:.:|.:..|.:|    |.||
Zfish     1 MMKCLLKPSPLVLIFIFSFTHAGNVL-VLP-GEYSHWQNMRNVVDELLNRNHTVTVLVCSASPTI 63

  Fly    62 -FPLKEPVAN-IHDIPV--PELFDNIEEIVGNLTNRKGTWNEFEYIN--QYTLGLVE-------- 112
             |..:|.... :.::|:  .||....||::       ..|.:....|  |..|.::|
Zfish    64 NFTQQERFQYLVFEVPLSAQELDGASEELI-------HIWTQHPSPNRLQTALQIIELLGRVRVM 121

  Fly   113 ------KVLENDGVRREILQPESLQFDLIIVDLWRLDALYGLAAYFDAPIIGIASYGTDWKIDEL 171
                  .:|.||.:   |.|..:|:||::..|...:.|.. ||.....|::........:.::.:
Zfish   122 HRAMCDSMLRNDAL---IAQLSALKFDVLFNDPMFMCADL-LAEMLGLPLVLSVRISPGFCLERM 182

  Fly   172 VGNV-SPLAYLQ-------------------------SPSF---NWFDLDTYGGRLGHFVDQSMA 207
            .|.: :|.:::.                         |.||   .|..||:|
Zfish   183 CGQMPAPPSFVPITQTVLTDRMCFMERVQNMIANIVFSVSFYIVAWISLDSY------------- 234

  Fly   208 WINWHWRHEERHEAVYRKYFPKIADKRSLSEITRNFALILVNQHFTMAPPRPYVPNIIEVGGMHV 272
                              |...:....::.|......:.|:..::....|||:.||...|||:|.
Zfish   235 ------------------YTDVLGKPTTMCETMGKADIWLIRTYWDFEYPRPFPPNFKFVGGLHC 281

  Fly   273 DQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVRSRNLSKDRRKILIDTFASLPQRILWKFDADEL 337
             :..|.|.:::|:|:|.:|:|||:.||||:.:  :||:.:|...:......:||:::|::.....
Zfish   282 -KPAKPLSKEMEEFVQSSGDHGVVVFSLGSMI--KNLTSERANTIAAALGQIPQKVVWRYSGKTP 343

  Fly   338 SDVPSNVLISPWFPQQDILAHPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQ 402
            ..:..|..|..|.||.|:|.||..|.||||||.....|.|:.||||:|||.|.||..|:.|:|.:
Zfish   344 ETLAPNTKIYDWIPQNDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFADQPDNLLHMKTK 408

  Fly   403 GIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAP 467
            |..:||:...:.|.:..|.:..:|...|:.....|.:..:.||||.|||.|::|..:|:|:|||.
Zfish   409 GAAVVLDINTLESKDLVDALKTVLNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAK 473

  Fly   468 HMRVAGRNLDFITYHSLDVLGTFLLAVWAILSI--VVLCAIKLLRAILKSKKGNISPKQK 525
            |:||....|.:..||.||| ..|||::.|:::.  |..|.....|.:.|::....:.|.|
Zfish   474 HLRVQAHELSWYQYHCLDV-AAFLLSIAALITFLWVKACCFLFRRCVRKTRPERKTQKSK 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	133/512 (26%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	115/468 (25%)
ugt2a2	NP_001018306.2	UDPGT	23..521	CDD:278624	145/545 (27%)
ugt2a2	NP_001018306.2	egt	<256..487	CDD:223071	86/233 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55988
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.860