Protein Alignment Ugt35E2 and UGT1A4

DIOPT Version :9

• Sequence 1: NP_652623.2
• Gene: Ugt35E2 / 53506
• FlyBaseID: FBgn0040255
• Length: 527
• Species: Drosophila melanogaster
• Sequence 2: NP_009051.1
• Gene: UGT1A4 / 54657
• HGNCID: 12536
• Length: 534
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 152/562 - (27%)
• Similarity: 269/562 - (47%)
• Gaps: 75/562 - (13%)

  Fly     1 MPMSMLVLRLIVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSPFPLK 65
            :|:..|...|: |::::.| ..|..::| |.|... |.:......|::|.:.||:...::
Human     7 VPLPRLATGLL-LLLSVQP-WAESGKVL-VVPTDG-SPWLSMREALRELHARGHQAVVLT----- 62

  Fly    66 EPVANIHDIPVPELFDNIEEIVGNLTNRKGTWNEFEYINQYTLGLVEKVLENDGVRR-------- 122
             |..|:| |...:.|        .||.....|.:.|: ::.|||..:...|.:.:.:
Human    63 -PEVNMH-IKEEKFF--------TLTAYAVPWTQKEF-DRVTLGYTQGFFETEHLLKRYSRSMAI 116

  Fly   123 -------------EILQPESL-------QFDLIIVDLWRLDALYGLAAYFDAPIIGIASY---GT 164
                         |:|..|:|       .||:::.|...|.... ||.|...|.:....|   ..
Human   117 MNNVSLALHRCCVELLHNEALIRHLNATSFDVVLTDPVNLCGAV-LAKYLSIPAVFFWRYIPCDL 180

  Fly   165 DWKIDELVGNVSPLAYLQSPSFNWFDLDTYGGRLGHFV-DQSMAWINWHWRHEERHEAVYRKYFP 228
            |:|..:.   .:|.:|:........|..|:..|:.:.: ..::::|.      ....|.|.....
Human   181 DFKGTQC---PNPSSYIPKLLTTNSDHMTFLQRVKNMLYPLALSYIC------HTFSAPYASLAS 236

  Fly   229 KIADKR-SLSEITRNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGE 292
            ::..:. |:.::....::.|....|.|..|||.:||::.:||::. ...|.|.|:.|.:|..:||
Human   237 ELFQREVSVVDLVSYASVWLFRGDFVMDYPRPIMPNMVFIGGINC-ANGKPLSQEFEAYINASGE 300

  Fly   293 HGVIYFSLGTNVRSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILA 357
            ||::.||||:.|  ..:.:.:...:.|....:||.:||::.....|::.:|.::..|.||.|:|.
Human   301 HGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLG 363

  Fly   358 HPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTI 422
            ||..:.||||.|.....|.|..||||:.:|.|.||..|.:.::.:|.|:.||..:|||::.::.:
Human   364 HPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENAL 428

  Fly   423 HQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVL 487
            ..::.:||:.....|.:..::|:|:.|||.|::|..:|:|||||||:|.|..:|.:..||||||:
Human   429 KAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVI 493

  Fly   488 GTFLLAVWAILSIVVL----CAIKLLRAILKSKKGNISPKQK 525
            | |||||  :|::..:    ||....:.:  .|||.:....|
Human   494 G-FLLAV--VLTVAFITFKCCAYGYRKCL--GKKGRVKKAHK 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	128/490 (26%)
		YjiC	26..440	CDD:224732	109/446 (24%)
UGT1A4	NP_009051.1	UDPGT	29..525	CDD:278624	145/531 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150572
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690