Protein Alignment Ugt35E2 and UGT1A9

DIOPT Version :9

• Sequence 1: NP_652623.2
• Gene: Ugt35E2 / 53506
• FlyBaseID: FBgn0040255
• Length: 527
• Species: Drosophila melanogaster
• Sequence 2: NP_066307.1
• Gene: UGT1A9 / 54600
• HGNCID: 12541
• Length: 530
• Species: Homo sapiens
• Alignment Length: 558
• Identity: 155/558 - (27%)
• Similarity: 269/558 - (48%)
• Gaps: 74/558 - (13%)

  Fly     2 PMSMLVLRLIVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSP----- 61
            |:.:.|..|:....|      |..::| |.|:.. ||::.....::||...|||:..|.|
Human     9 PLPLCVCLLLTCGFA------EAGKLL-VVPMDG-SHWFTMRSVVEKLILRGHEVVVVMPEVSWQ 65

  Fly    62 ---------------FPLKEPVANIHDIPVPELFDNIEEIVGNLTNRKGTWNE-FE--YINQYTL 108
                           :.|::...........:....:..|...|   .|::|: |:  :.|..:|
Human    66 LGRSLNCTVKTYSTSYTLEDLDREFKAFAHAQWKAQVRSIYSLL---MGSYNDIFDLFFSNCRSL 127

  Fly   109 GLVEKVLENDGVRREILQPESLQFDLIIVDLWRLDALYGLAAYFDAPIIGIASYGTDWKIDELVG 173
            ...:|::       |.|:..|  ||.:.:|.:....|. :|.||..|.:..|.......::|...
Human   128 FKDKKLV-------EYLKESS--FDAVFLDPFDNCGLI-VAKYFSLPSVVFARGILCHYLEEGAQ 182

  Fly   174 NVSPLAYLQSPSFNWFDLDTYGGRLGHFVDQSMAWINWHWRHEERHEAVYR--KYFPKIADKRSL 236
            ..:||:|:......:.|..|:..|:.:           |..|.|.|...:|  |...:||.:...
Human   183 CPAPLSYVPRILLGFSDAMTFKERVRN-----------HIMHLEEHLLCHRFFKNALEIASEILQ 236

  Fly   237 SEITR-----NFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVI 296
            :.:|.     :.::.|:...|.:..|:|.:||:|.:||::. .|.|.||.:.|.:|..:||||::
Human   237 TPVTEYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINC-HQGKPLPMEFEAYINASGEHGIV 300

  Fly   297 YFSLGTNVRSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPNV 361
            .||||:.|  ..:.:.:...:.|....:||.:||::.....|::.:|.::..|.||.|:|.||..
Human   301 VFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMT 363

  Fly   362 KLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLL 426
            :.||||.|.....|.|..||||:.:|.|.||..|.:.::.:|.|:.||..:|||::.::.:..::
Human   364 RAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVI 428

  Fly   427 TEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFL 491
            .:||:.....|.:..::|:|:.|||.|::|..:|:|||||||:|.|..:|.:..||||||:| ||
Human   429 NDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIG-FL 492

  Fly   492 LAVWAILSIVVL----CAIKLLRAILKSKKGNISPKQK 525
            |||  :|::..:    ||....:.:  .|||.:....|
Human   493 LAV--VLTVAFITFKCCAYGYRKCL--GKKGRVKKAHK 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	132/487 (27%)
		YjiC	26..440	CDD:224732	113/443 (26%)
UGT1A9	NP_066307.1	UDPGT	26..521	CDD:278624	149/528 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150334
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690