DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and UGT1A6

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001063.2	Gene:	UGT1A6 / 54578	HGNCID:	12538	Length:	532	Species:	Homo sapiens

Alignment Length:	523	Identity:	156/523 - (29%)
Similarity:	261/523 - (49%)	Gaps:	65/523 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHYYHALPYLKKLASLGHEITSVSP---FPLKEPVANIHDI-PVPELFDNIEEIVGNLTNRKGTW 97
            ||:......::.|:..||||..|.|   ..|||.......| |||  :|..|     |.||..::
Human    37 SHWLSMKDIVEVLSDRGHEIVVVVPEVNLLLKESKYYTRKIYPVP--YDQEE-----LKNRYQSF 94

  Fly    98 --NEF-----------EY-INQYTLGL----VEKVLENDGVRREILQ--PESLQFDLIIVDLWRL 142
              |.|           || .|...:||    .:.:|::    |:.|.  .|| :||.:..|. .|
Human    95 GNNHFAERSFLTAPQTEYRNNMIVIGLYFINCQSLLQD----RDTLNFFKES-KFDALFTDP-AL 153

  Fly   143 DALYGLAAYFDAPIIGIASYGTDWKIDELVG-NVSPLAYLQSPSFNWFDLDTYGGRLGHFVDQSM 206
            .....||.|...|.:.:.. |....::.... :..|::|:......:.|..|:..|:.:|:...:
Human   154 PCGVILAEYLGLPSVYLFR-GFPCSLEHTFSRSPDPVSYIPRCYTKFSDHMTFSQRVANFLVNLL 217

  Fly   207 AWINWHW---RHEERHEAVYRKYFPKIADKRSLSEIT--RNFALILVNQHFTMAPPRPYVPNIIE 266
            ....::.   ::||...||.         ||.:..||  :..::.|:...|.:..|||.:||::.
Human   218 EPYLFYCLFSKYEELASAVL---------KRDVDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVF 273

  Fly   267 VGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVRSRNLSKDRRKILIDTFASLPQRILWK 331
            :||::..:: |.|.|:.|.:|..:||||::.||||:.|  ..:.:.:...:.|....:||.:||:
Human   274 IGGINCKKR-KDLSQEFEAYINASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWR 335

  Fly   332 FDADELSDVPSNVLISPWFPQQDILAHPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNM 396
            :.....|::.:|.::..|.||.|:|.||..:.||||.|.....|.|..||||:.:|.|.||..|.
Human   336 YTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNA 400

  Fly   397 EHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVL 461
            :.::.:|.|:.||..:|||::.::.:..::.:||:.....|.:..::|:|:.|||.|::|..:|:
Human   401 KRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVM 465

  Fly   462 RHKGAPHMRVAGRNLDFITYHSLDVLGTFLLAVWAILSIVVL----CAIKLLRAILKSKKGNISP 522
            |||||||:|.|..:|.:..||||||:| |||||  :|::..:    ||....:.:  .|||.:..
Human   466 RHKGAPHLRPAAHDLTWYQYHSLDVIG-FLLAV--VLTVAFITFKCCAYGYRKCL--GKKGRVKK 525

  Fly   523 KQK 525
            ..|
Human   526 AHK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	137/473 (29%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	119/432 (28%)
UGT1A6	NP_001063.2	egt	15..506	CDD:223071	150/497 (30%)
UGT1A6	NP_001063.2	UDPGT	27..523	CDD:278624	155/516 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150643
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690