Protein Alignment Ugt35E2 and UGT1A7

DIOPT Version :9

• Sequence 1: NP_652623.2
• Gene: Ugt35E2 / 53506
• FlyBaseID: FBgn0040255
• Length: 527
• Species: Drosophila melanogaster
• Sequence 2: NP_061950.2
• Gene: UGT1A7 / 54577
• HGNCID: 12539
• Length: 530
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 158/549 - (28%)
• Similarity: 267/549 - (48%)
• Gaps: 64/549 - (11%)

  Fly    10 LIVLVVALLPV--LLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSPFPLKEPVANIH 72
            |:.|.|.||..  ..:..::| |.|:.. ||::.....::||...|||:..|.| .:...:....
Human     9 LLPLYVCLLLTCGFAKAGKLL-VVPMDG-SHWFTMQSVVEKLILRGHEVVVVMP-EVSWQLGRSL 70

  Fly    73 DIPVP------ELFDNIEEIVGNLTNRKGTW-----NEFEYINQYTLGLVE------KVLENDGV 120
            :..|.      .|.|...|.   :......|     :.|..:...:.|:.:      :.|.||..
Human    71 NCTVKTYSTSYTLEDQDREF---MVFADARWTAPLRSAFSLLTSSSNGIFDLFFSNCRSLFNDRK 132

  Fly   121 RREILQPESLQFDLIIVDLWRLDALYGLAAYFDAPIIGIASYGTDWKIDELVGNVSPLAYLQSPS 185
            ..|.|: ||. ||.:.:|.:....|. :|.||..|.:..|.......::|.....:||:|:....
Human   133 LVEYLK-ESC-FDAVFLDPFDACGLI-VAKYFSLPSVVFARGIFCHYLEEGAQCPAPLSYVPRLL 194

  Fly   186 FNWFDLDTYGGRLGHFVDQSMAWINW-HWRHEERHEAVYRKYFPK----IADKRSLSEIT----- 240
            ..:.|..|:..|:            | |..|.|.|  ::..||.|    ||.:...:.:|
Human   195 LGFSDAMTFKERV------------WNHIMHLEEH--LFCPYFFKNVLEIASEILQTPVTAYDLY 245

  Fly   241 RNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVR 305
            .:.::.|:...|.:..|:|.:||:|.:||::. .|.|.:|.:.|.:|..:||||::.||||:.|
Human   246 SHTSIWLLRTDFVLEYPKPVMPNMIFIGGINC-HQGKPVPMEFEAYINASGEHGIVVFSLGSMV- 308

  Fly   306 SRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPNVKLFITHGGL 370
             ..:.:.:...:.|....:||.:||::.....|::.:|.::..|.||.|:|.||..:.||||.|.
Human   309 -SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGS 372

  Fly   371 QSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKA 435
            ....|.|..||||:.:|.|.||..|.:.::.:|.|:.||..:|||::.::.:..::.:||:....
Human   373 HGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENI 437

  Fly   436 KRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLAVWAILSI 500
            .|.:..::|:|:.|||.|::|..:|:|||||||:|.|..:|.:..||||||:| |||||  :|::
Human   438 MRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIG-FLLAV--VLTV 499

  Fly   501 VVL----CAIKLLRAILKSKKGNISPKQK 525
            ..:    ||....:.:  .|||.:....|
Human   500 AFITFKCCAYGYRKCL--GKKGRVKKAHK 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	134/484 (28%)
		YjiC	26..440	CDD:224732	116/440 (26%)
UGT1A7	NP_061950.2	UDPGT	26..521	CDD:278624	152/525 (29%)
		egt	<264..504	CDD:223071	91/245 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150333
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690