DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E2 and Ugt37C1

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_525007.1	Gene:	Ugt37C1 / 53583	FlyBaseID:	FBgn0026754	Length:	485	Species:	Drosophila melanogaster

Alignment Length:	512	Identity:	155/512 - (30%)
Similarity:	245/512 - (47%)	Gaps:	65/512 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 KKLASLGHEITSVSPFPLKEPVANIHDIPVPELFDNIEEIVGNLTNRKGTWNEFEYINQYTL--G 109
            |.||..||.:|.||....|....:||.|.||...:....:...:.:..|:.|.. ....|.|  |
  Fly     5 KALAEAGHNVTVVSMMQPKVMHKDIHLIVVPVTKEQERTLENQMASMAGSKNNI-ITTMYLLLNG 68

  Fly   110 LVEKVLENDGVRREILQPESLQ------FDLIIVDLWRLDALYGLAAYFDAPIIGIASYGTDW-- 166
            |...|..    :.::|:....|      |||:|:..:..|...|:|.....|:|      .||
  Fly    69 LDVMVTS----QADLLKDPRFQRVFETKFDLMILGSFFNDFQLGVAGKLKVPVI------VDWMI 123

  Fly   167 ----KIDELVGNVSPLAYLQSPSFNWFDLDTYGGRLGHFVDQSMAWINWHWRHEERHEAVYRKY- 226
                .|||.|.|.|.::|:.:.|              .|....|::..   |.|...:.|..||
  Fly   124 PSNTMIDEFVANPSEVSYVPNES--------------TFATTPMSFFK---RAENLVKHVILKYL 171

  Fly   227 -------FPKI-------ADKRSLSEITRNFALILVNQH-FTMAPPRPYVPNIIEVGGMHVDQQP 276
                   |.:|       .|..:|||:.:|.:::.|..| .:..|.||.||.||||||:.|.:||
  Fly   172 TIRFNYKFNRIYNEIFTDKDMPTLSEMKKNISMVFVGSHLISDGPIRPLVPAIIEVGGIQVKEQP 236

  Fly   277 KALPQDLEDFIQGAGEHGVIYFSLGTNVRSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVP 341
            ..||||:|.|::.:.: |.|:.|.|:|::|..:..:...|:....:.|.|.::||:  ::|.:.|
  Fly   237 DPLPQDIEQFMENSSQ-GAIFLSFGSNIKSYMVKPEIVGIMFKVLSGLKQNVIWKW--EDLENTP 298

  Fly   342 ---SNVLISPWFPQQDILAHPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQG 403
               ||:....|.||.|||||||.|||:||.|..|..|..:.||||:.||.|.|...|...:...|
  Fly   299 GNASNIFYKDWLPQDDILAHPNTKLFVTHAGKGSITESQYHGVPMVALPIFGDHPLNAALMVNSG 363

  Fly   404 IGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPH 468
            .|:.|:.:.:|.|.|::.|:::|....:....::.:..|||:|:.|..:.::|..|||||.|||:
  Fly   364 YGVSLDLQTITEDTFREAINEVLENDKYTQAVRKFSALYRDRPLTPRQSVLFWVDYVLRHHGAPN 428

  Fly   469 MRVAGRNLDFITYHSLDVLGTFLLAVWAILSIVVLCAIKLLRAILKSKKGNISPKQK 525
            ::....::.|:..|:||:. ..:||:...|..:....:|.|.:.|..|....:.|:|
  Fly   429 LQSPAVHMGFVELHNLDIY-ALVLAILIFLVFLTRLTVKFLFSKLLGKAKVPARKKK 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	143/466 (31%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	128/425 (30%)
Ugt37C1	NP_525007.1	UDPGT	1..477	CDD:278624	153/503 (30%)
Ugt37C1	NP_525007.1	egt	6..433	CDD:223071	141/457 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445749
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.850