DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E2 and Ugt37C2

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster

Alignment Length:	562	Identity:	160/562 - (28%)
Similarity:	263/562 - (46%)	Gaps:	84/562 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MLVLRLIVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSPFPLKEPVA 69
            |:.:..:.|::..:....:||.|||:|...|.||....:...|.|...||.:|.||....|....
  Fly     1 MIGVHFVFLLLLGVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVVSMLKPKVTHK 65

  Fly    70 NIHDIPVPE-------LFDNIEEIVGNLTNRKGTWNEFEYINQYTLGLVEKVLENDGVRREILQP 127
            :||.|.||.       :.|.:.|:.|...:...|        .|.|.....|:.|  .:.|:|..
  Fly    66 DIHLIVVPMKEEQERIMEDQMTEMAGQKNSLVST--------MYRLLTSMDVMIN--AQAELLSD 120

  Fly   128 ESLQ------FDLIIVDLWRLDALYGLAAYFDAPIIGIASYGTDW------KIDELVGNVSPLAY 180
            ...|      |||:|:..:..|...|:|.....|:|      .:|      .||:..||.|.|:|
  Fly   121 PRFQRIYETKFDLMILGYFINDFQLGVAHKLKVPVI------INWMSAPVPAIDKYTGNPSELSY 179

  Fly   181 LQSPSFNWFDLDTYGGRLGHFVDQSMAWINWHWRHEERHEA----------------VYRKYFPK 229
            :.              .:|....|.|.::.   |.|...::                :|...||:
  Fly   180 VP--------------LMGTVATQPMGFLK---RTENALKSLLFEFIFVVFDYKLTRIYNDVFPE 227

  Fly   230 IADKRSLSEITRNFALILVNQH-FTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEH 293
             .|..:|.|:.:|.::..|..| .:..|.||.||.:||:||:.|..:|..||:|::.||..| :.
  Fly   228 -QDMPTLKELRKNISMAFVGSHLISEGPIRPLVPALIEIGGIQVKDKPDPLPKDIDQFISNA-KQ 290

  Fly   294 GVIYFSLGTNVRSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVP---SNVLISPWFPQQDI 355
            |.::.|||:||:|..:..:..:|:....:.|.:.::||:  ::|.:.|   ||:|...|.||.||
  Fly   291 GAVFLSLGSNVKSSTVRPEIVQIIFKVLSELKENVIWKW--EDLENTPGNSSNILYKNWLPQDDI 353

  Fly   356 LAHPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKD 420
            |||||.||||||.|.....|..:.||||:.||.|.||..|...::..|.||.|:...:|.|..:|
  Fly   354 LAHPNTKLFITHAGKGGITEAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRD 418

  Fly   421 TIHQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLD 485
            .:.::|..:.:.....:.:..|||:||....:.::||.|:|||:|||:::....:::||..::||
  Fly   419 ALKEVLENQKYKQAIGQFSTLYRDRPMTAKQSVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLD 483

  Fly   486 VLGTFLLAVWAILSIVVLCAIKLLRAILKSKKGNISPKQKIN 527
                    ::|::..:::..:.|.|.:.|........|.||:
  Fly   484 --------IYALIVTILVLFVLLTRLVAKIVWNKFGGKAKIS 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	149/496 (30%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	131/452 (29%)
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	149/502 (30%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	149/526 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445693
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.850