DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and Ugt37D1

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	167/549 - (30%)
Similarity:	278/549 - (50%)	Gaps:	56/549 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LIVLVVAL--LPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSPFPLKEPVANIH 72
            |:|.::||  :|...|||.|||||...|.||:...:..:|.||..||.:|.||..|.|....:|:
  Fly    16 LLVALLALQTMPQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSSVPPKVTHKSIN 80

  Fly    73 DIPVPELFDNIEEIV-----GNLTNRKGTWNEFEYINQYTLGLVEK---VLENDGVRREILQPES 129
            .|.||...:: |:::     |.:..:...||..:.|......|::|   ||| |...:|:...:.
  Fly    81 HIVVPMSAED-EKVLNDGMAGMVKEKPSIWNTMKSIFSSLALLIDKQVDVLE-DPRFQELYLNKG 143

  Fly   130 LQFDLIIVDLWRLDALYGLAAYFDAPIIGIASYGTDWK------IDELVGNVS----PLAYLQSP 184
            .:||::.|..:.......|.|.|:.|:|      ..|.      ::|::||..    |..::.:|
  Fly   144 NKFDVVFVGFFFNTYQVALGARFNCPVI------ISWSGPPMMMVNEVLGNPELSSVPQMHISAP 202

  Fly   185 ---SFNWFD-LDTYGGRLGHFVDQSMAWINWHWRHEERHEAVYRKYFPKIADK----RSLSEITR 241
               ..|:.. :..:...||...      :|....|:      |.|::.::..|    .:.::..|
  Fly   203 PGQPMNFQQRMQNFASTLGFNA------LNIFLNHK------YNKFYDRLWSKDKSMPTFAQAKR 255

  Fly   242 NFALILVNQH-FTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVR 305
            |.:|...|.| .:..|.||.||.:||:||:.|..:|..||:|:::|:: .|:||.|.||||:|::
  Fly   256 NVSLAFCNGHGISEGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLE-KGKHGAILFSLGSNLK 319

  Fly   306 SRNLSKDRRKILIDTFASLPQRILWKF-DADELSDVPSNVLISPWFPQQDILAHPNVKLFITHGG 369
            ..::..:..|.:....:||.|:::||: |........:|:|...|.||.||||||.:||||||.|
  Fly   320 GEHIQPEVVKTIFKGLSSLKQQVIWKWEDPKNTPGKSANILYKKWLPQDDILAHPKLKLFITHAG 384

  Fly   370 LQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVK 434
            .....|..:.|||||.||.|.||..|.:.:.|.|.||.|....:..||||..|.:::....:...
  Fly   385 KGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEFKAAIKEVIENPKYAKT 449

  Fly   435 AKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLAVWAILS 499
            .|..:..|||:|::|.::.::||.||:||.||.||:....:::||..::||:   :::|...:..
  Fly   450 LKSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPLVHMNFIASNNLDI---YIIAALVLYI 511

  Fly   500 IVVLCAI--KLLRAILKSKKGNISPKQKI 526
            :.::..|  |.:...|..|...:|..:|:
  Fly   512 VFIINKIVWKFVWRKLFGKSNKVSKGKKV 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	153/485 (32%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	133/441 (30%)
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	157/510 (31%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	150/508 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445707
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950