DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and Ugt35C1

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001097744.1	Gene:	Ugt35C1 / 53507	FlyBaseID:	FBgn0040256	Length:	517	Species:	Drosophila melanogaster

Alignment Length:	515	Identity:	210/515 - (40%)
Similarity:	325/515 - (63%)	Gaps:	24/515 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MLVLRLIVLVVALL---PVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSPFPLKE 66
            |.:|.:|.:|...|   |:..|.|:||...|.|..|.|.....|||.||:.||::|.::.|..||
  Fly     1 MRLLTVIAIVFCALSAKPLESESAKILATLPFPGRSQYIFVESYLKALAAKGHQVTVINAFKNKE 65

  Fly    67 PVANIHDIPVPELFDNIEEIVGNLTNRKGTW---NEFEYI-NQYTLGLVEKVLENDGVRREILQP 127
             ..|:..|...:..:..:|:: :|.|....|   |..:|| |::    ::..:|::||:|.:...
  Fly    66 -TPNMRFIEALKAHEFADEMM-SLLNVPLLWQQLNAMDYILNKF----IDVTMEDEGVQRLLNSG 124

  Fly   128 ESLQFDLIIVDLWRLDALYGLAAYFDAPIIGIASYGTDWKIDELVGNVSPLAY---LQSPSFNWF 189
            |:  |||::.::..::.:|..|.:|:|.::|.:|:|||..|||..||:||::|   :.||.   .
  Fly   125 ET--FDLVLAEMLHMEPMYAFAQHFNATLVGFSSFGTDRTIDEAAGNISPISYNPLVTSPR---T 184

  Fly   190 DLDTYGGRLGHFVDQSMAWINWHWRHEERHEAVYRKYFPKIADKRSLSEITRNFALILVNQHFTM 254
            |..|:..||.:..:..:..|:.|:.|......||:||||..  |::|.|:..:|:|||:.|||::
  Fly   185 DRMTFLERLENHYEVIVEDIHRHFVHLPHMRNVYKKYFPNA--KKTLEEVMDSFSLILLGQHFSL 247

  Fly   255 APPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVRSRNLSKDRRKILID 319
            :.||||:||:|||||||:..:||.||:|::.||:|: .|||||||:|:||:|::|.::.|..|:.
  Fly   248 SYPRPYLPNMIEVGGMHISHKPKPLPEDIKQFIEGS-PHGVIYFSMGSNVKSKDLPQETRDTLLK 311

  Fly   320 TFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPNVKLFITHGGLQSTVECIHRGVPML 384
            |||.|.||:||||:.|::...|:||||..|:||.||||||||||||:||||.|:.|.::.|.|:|
  Fly   312 TFAKLKQRVLWKFEDDDMPGKPANVLIKKWYPQPDILAHPNVKLFISHGGLLSSTESVYFGKPIL 376

  Fly   385 GLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKRTADRYRDQPMNP 449
            |||.||||..|::..:..|.||.|:..::..::.:..|..|||:.|:...:...::||||||.:.
  Fly   377 GLPCFYDQHMNVQRAQRVGFGLGLDLNNLKQEDLEKAIQTLLTDPSYAKASLAISERYRDQPQSA 441

  Fly   450 LDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLAVWAILSIVVLCAIKLL 509
            :|.|:|||.||:||.||||:|...|:|:||..:|||.|...|.....:..::|..:.|||
  Fly   442 VDRAVWWTEYVIRHNGAPHLRATSRDLNFIQLNSLDTLAVILAVPLLLALLIVTLSCKLL 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	195/464 (42%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	169/420 (40%)
Ugt35C1	NP_001097744.1	egt	1..470	CDD:223071	199/482 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	1	1.000	-	-		H55988
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	1	0.950	-	0	Normalized mean entropy	S5046
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D45181at50557
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	12	11.820