DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and RGD1559459

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	XP_003751392.1	Gene:	RGD1559459 / 501907	RGDID:	1559459	Length:	530	Species:	Rattus norvegicus

Alignment Length:	555	Identity:	153/555 - (27%)
Similarity:	273/555 - (49%)	Gaps:	68/555 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPMSMLVLRLIVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSP---- 61
            |..::|:|.|.:...:     ..|.::| |:|: ..||:.:....|.:|...|||:..:.|
  Rat     5 MTAALLLLHLTIFFGS-----GSGGKVL-VWPV-EFSHWLNLKIILSELVKKGHEVVVLKPSVSF 62

  Fly    62 --------------FPLKEPVANIHDIPVPELFDNIEEIVGNLTNRKGTWNEF---EYINQYTLG 109
                          ||....:|::..|    ..|.:.|.:..|. ::..|..|   :.:.:.|..
  Rat    63 SYEVDKTSAIEFESFPSSYSIADVEVI----FMDCVNESIYELP-KQSFWGYFLMLQKLFERTSD 122

  Fly   110 LVEKVLENDGVRREIL-QPESLQFDLIIVD-----------LWRLDALYGLAAYFDAPIIGIASY 162
            ..|::..:....:|:: :.::..||:|:.|           :.::..:|.|..:   |......|
  Rat   123 YSERLCRDAAFNKELMTKLQNSGFDVILADPFTPCGDLLAEILKIPLVYSLRFF---PGSTYEKY 184

  Fly   163 GTDWKIDELVGNVSPLAYLQSPSFNWFDLDTYGGRLGHFVDQSMAWINWHWRHEERHEAVYRKYF 227
            ..        |...|.:|:........|..|:..|:.|.: ..:.:..|....:|:.   :.:.:
  Rat   185 SG--------GLPMPPSYVPIAMSELSDRMTFVERVKHMI-YVLCFDFWFQVFDEKK---WNELY 237

  Fly   228 PKIADK-RSLSEITRNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAG 291
            .::..: .:|||......:.|:..::.:..|.|.:||...|||:|. :..|.||:::|||:|.:|
  Rat   238 TEVLGRPTTLSETMAKADIWLIRTYWDLEFPHPVLPNFDFVGGLHC-RPAKPLPKEIEDFVQSSG 301

  Fly   292 EHGVIYFSLGTNVRSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDIL 356
            ||||:.||||:.|.|  |:::|..::....|.:||::||:|:..:...:.||..:..|.||.|:|
  Rat   302 EHGVVVFSLGSMVGS--LTEERANVIAAGLAQIPQKVLWRFEGKKPETLGSNTRLYKWIPQNDLL 364

  Fly   357 AHPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDT 421
            .||..:.||||||.....|.|:.|:|::|:|.|.||..|:.|:|.:|..:.|::..|:|.:....
  Rat   365 GHPKTRAFITHGGTNGIYEAIYHGIPVVGIPLFGDQKDNIVHLKTKGAAVRLDFLTMSSTDLLTA 429

  Fly   422 IHQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDV 486
            :..:..:.|:...|.|.:..:.|||:.|||.|::|..:|:|||||.|:||||.:|.::.||||||
  Rat   430 LRTVTNDPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAGHDLSWVQYHSLDV 494

  Fly   487 LGTFLLAVWAILSIV----VLCAIKLLRAILKSKK 517
            :|..|..|..::.|:    :.|..|..:|..|.||
  Rat   495 IGFLLACVVTVMFILKKCCLFCCQKFTKAGRKKKK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	133/491 (27%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	112/447 (25%)
RGD1559459	XP_003751392.1	UDPGT	24..527	CDD:278624	145/527 (28%)
RGD1559459	XP_003751392.1	egt	<270..508	CDD:223071	96/240 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344061
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690