DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E2 and Ugt36A1

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	568	Identity:	162/568 - (28%)
Similarity:	273/568 - (48%)	Gaps:	87/568 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LRLIVLVVALLPVL-----LEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSPFPLKEP 67
            ||..||::.||.:|     :....||.|:|....||:...:|.|.:||..||:||.:|  .:|.|
  Fly     5 LRSGVLIIVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVIS--YVKNP 67

  Fly    68 VANIHDIPVPELFDNIEEIVGN---------------LTNRKGTWN----EFEYINQYTLG--LV 111
            .|.        .:.|.||::.:               ||....|.:    ..||::.:..|  ..
  Fly    68 QAG--------AYPNYEELLISAPGEDQSSTTINLVPLTEHTPTRSLGVLIREYVDLHEEGQKTC 124

  Fly   112 EKVLENDGVRREILQPESLQFDLIIVDLWRLDALYGLAAYFDAPIIGIAS-----YGTDWKIDEL 171
            |.:..:..:.|.|.:..:..:||::.:.:..|....||...:.||||:::     |..| :||
  Fly   125 EHLFASGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPIIGLSTCALMPYYYD-RID-- 186

  Fly   172 VGNVSPLAYLQSPSFNWFDLDTYGGRLGHFVDQSMAWINWHWRHEERHEAVYRKYFPKIADKRSL 236
                    ...:|:|...:...:.|:|           |||.|.....:|...|:..|....|:.
  Fly   187 --------LPDTPAFIQSEFVGFAGQL-----------NWHERLLNFVQAKLLKFLYKYHSNRAD 232

  Fly   237 SEITRNF---------------ALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQ-PKALPQDLED 285
            :|:.|.:               |.|..|||:::...||.....:|:||:|:.:: .:.|||::.:
  Fly   233 NELVRKYLGVEVDVEEVARTQTAFIFGNQHYSLMGSRPQSLQFVEIGGVHITKKAEQELPQNIAN 297

  Fly   286 FIQGAGEHGVIYFSLGTNVRSRNLSKDRRKILIDTFASLPQRILWKFDADELSDV-PSNVLISPW 349
            |:..:.| |||:.|.|:.||:.::.:|:...:::...|.|.:|:||::|||..|. .|..|...|
  Fly   298 FLNQSAE-GVIFISWGSMVRASSIDEDKLSAILEVLKSQPLKIIWKWEADETPDTDASKFLFVKW 361

  Fly   350 FPQQDILAHPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMT 414
            .||..:|.||.||||.:||||..|.|.:|.|.|:|..|.:.|||.|...::.:|:||.|:|:|:|
  Fly   362 APQLALLCHPKVKLFWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDIT 426

  Fly   415 SDEFKDTIHQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHK--GAPHMRVAGRNLD 477
            ....|..:.: |::.|:..::...:..:.::...||::|||...:|:.:.  .|..::..|..|:
  Fly   427 VPNLKKALAE-LSKNSYAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELN 490

  Fly   478 FITYHSLDVLGTFLLAVWAILSIVVLCAI-KLLRAILKSKKGNISPKQ 524
            ...|||||.:...||.:  ||.|:|||.: |...:.|..||....||:
  Fly   491 GFVYHSLDSVALILLPL--ILLILVLCYLCKRNPSKLAHKKVGKKPKR 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	136/502 (27%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	127/456 (28%)
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	138/500 (28%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	137/496 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454662
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.990