DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E2 and Ugt303B1

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	173/535 - (32%)
Similarity:	295/535 - (55%)	Gaps:	53/535 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LRLIVLVVALLPVL----LEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSPFPLKEPV 68
            ||...|.::|..:|    .:.|.|||:||....|.::...|.::.||:.||.:|.::|..:...:
  Fly     3 LRYCWLTLSLCLLLQHDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITPIGMPNDI 67

  Fly    69 ANIHDIPVPELFDNIEEIVGN------LTNRKGTWNEFEYINQYTLGLVEKVLENDGVRREILQP 127
            ..:..|.|.:|.:.|:|::.:      :.|:   |.|.....:........:|.:.||:| :|..
  Fly    68 EGVRHIRVAQLNERIKEMLESDQVLDFMINK---WTESALTAKALFNASNDILSDPGVQR-MLHD 128

  Fly   128 ESLQFDLIIVDLWRLDALYGLAAYFDAPIIGIASYGTDWKIDELVGNVSPLAY------------ 180
            :|..|||||::...|||||||..:::|.::|::|...:|...||.||.:|..|
  Fly   129 KSESFDLIIMEPSSLDALYGLVEFYNATLMGLSSIRINWHTYELAGNPAPSIYEPISPVGFSLET 193

  Fly   181 -LQSPSFNWFDLDTYGGRLGHFVDQSMAWINW-HWRHEERHEAVYRKYFPKIADKRSLSEITRNF 243
             |.|..:||.          |.:::.:  :|: ..|..:.|  :::|:|...|.|  ::|:...|
  Fly   194 SLFSRVYNWI----------HIMEEKL--VNYLILRPAQLH--LFQKFFGYSAQK--MNELRSRF 242

  Fly   244 ALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVRSRN 308
            :|:|:|.|::|...|...||||||||:|:.:.|:...::|:.|:..| :|||||||:|.::..:.
  Fly   243 SLMLINSHYSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQKFLDKA-DHGVIYFSMGNDILIKF 306

  Fly   309 LSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPNVKLFITHGGLQST 373
            |.::.:::|:.|||:|.:.|:||.:...:.|...||.:....||:.||.||||:||||:|||.|.
  Fly   307 LPENIQELLLQTFATLNESIIWKSELLYMPDKSDNVYVVEQAPQRHILNHPNVRLFITNGGLLSV 371

  Fly   374 VECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKRT 438
            :|.:..||||||||.|:|||.||..::..|:..|::...:..|...:||..:|...|:.:|||..
  Fly   372 IEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSLNKDTLTETIKHMLANNSYYLKAKEI 436

  Fly   439 ADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLL--------AVW 495
            :..::|:||:|||||:|||.|.||::....||:....:..|.|:.:|.:..|.|        .::
  Fly   437 SQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIEYYRIDSILAFSLRFGLVAASLIF 501

  Fly   496 AILSIVVLCAIKLLR 510
            .:.::.:...|:|.|
  Fly   502 LVYTLFLKYRIRLRR 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	161/477 (34%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	143/433 (33%)
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	158/461 (34%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	158/490 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445597
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D45181at50557
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	11	10.800