DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E2 and Ugt37A3

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	169/545 - (31%)
Similarity:	288/545 - (52%)	Gaps:	49/545 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MSMLVLRLIVLVVALLPVL--LEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSPFPLK 65
            |.:.|.:.::|.:|:..|:  .:||.|||:||..|.||....:...|.||..||.:|.|:   :.
  Fly     1 MVLRVEKFLLLAIAIGAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVT---VL 62

  Fly    66 EPVANIHDIPVPELFDNIEEIVGNLTNRKGTWNEFEYINQYTLGLVE-------------KVLEN 117
            :||.|..:|.|.::..:.|| ...:::..|..::.:..|. .|.|:.             :.|.|
  Fly    63 KPVVNHKNITVIQVPLSKEE-AQQMSDTIGAMSKNDNSNM-ALSLLRMSDQMDFMIRKNAETLMN 125

  Fly   118 DGVRREILQPESLQFDLIIVDLWRLDALYGLAAYFDAPIIGIASYGTDWKIDELVGNVSPLAY-- 180
            |.| |::......:|||:|...:..|...|.|...:||:|.:|:...:..::.|:||...::|
  Fly   126 DRV-RDLYLNRGNKFDLVISGYFMNDFQLGFARKVNAPVIVLATMPPNHLLNPLIGNPLEVSYAG 189

  Fly   181 LQSPSFNWFDLDTYGGRLGHFVDQSMAWINWHWRHEERHEAVYRKYF---PKIADKRSLSEITRN 242
            :.:|: ......|:..||..:: ||:.:..:....|.|:...|::.:   ||:.:   .||:.:|
  Fly   190 ISNPA-EGSKAVTFQRRLSSYM-QSLGFGVFSHLSERRNRNWYKEVYGNDPKMPE---YSEMLKN 249

  Fly   243 FALILVNQH-FTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVRS 306
            .:|:..:.| .:..|.||.||:.||:||:.:..:|..|||::.:|: |....|.|..|||:||:.
  Fly   250 TSLVFFSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFL-GNATDGAILLSLGSNVQG 313

  Fly   307 RNLSKDRRKILIDTFASLPQRILWKFDADELSDVP---SNVLISPWFPQQDILAHPNVKLFITHG 368
            ::|:.|....:.:..:.|.:|::||::..|  :.|   :|:|.|.|.||.|||||||:||||.|.
  Fly   314 KHLNPDTVAKMFNVLSKLKERVIWKWEDQE--NTPGKSANILYSKWLPQDDILAHPNIKLFINHA 376

  Fly   369 GLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGV 433
            |.....|..:.|.|||.||.|.||.||...:...|.||.|:...:....|::.|.::|:...:..
  Fly   377 GKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEEKPFQEAILEILSNPQYAE 441

  Fly   434 KAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLAVWAIL 498
            :.|..:..|||:||...::.::||.||:||.||.|::....::.||..:::|:  .||:.| .::
  Fly   442 RVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDI--CFLIFV-ILV 503

  Fly   499 SIVVLCAIKLL------RAILKSKK 517
            |::||  ||.|      |.|.|.||
  Fly   504 SVLVL--IKFLVQFIYRRFISKPKK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	149/479 (31%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	131/435 (30%)
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	154/502 (31%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	154/507 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445791
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	9.000