DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E2 and Ugt316A1

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001287111.1	Gene:	Ugt316A1 / 40079	FlyBaseID:	FBgn0036842	Length:	636	Species:	Drosophila melanogaster

Alignment Length:	547	Identity:	152/547 - (27%)
Similarity:	259/547 - (47%)	Gaps:	45/547 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LIVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKL--ASLGHEITSVSPFPLKEPVANIH 72
            |.|.:..||..::.||.:|.|||....|||......|::|  :|..|.:|.:||...:|.|
  Fly     4 LQVFLGTLLCGIVLGANVLTVFPSVWKSHYLFGRRLLQELVESSGNHSVTLISPHAAQEGV---- 64

  Fly    73 DIPVPELFDNIEEIVGNLTNRKGTWNE----FEYINQYTLGLVEK--------------VLENDG 119
            |..:|:    |.|:  .:...:..|.:    ||........::|:              :|.:..
  Fly    65 DAEIPK----IREL--RIEGLRENWLDMGMSFEAEEMRAQSVMERFTRLIYAGTTNVDILLSDPQ 123

  Fly   120 VRREILQPESLQFDLIIVDLWRLDALYGLAAYFDAPIIGIASYGTDWKIDELVGNVSPLAYLQSP 184
            ||:.:...|  :|||:||||:..|||.|||.|:..|.:.::..|.:..::.:.||  |.:....|
  Fly   124 VRKLLTSGE--KFDLLIVDLFLSDALLGLAFYYGIPTVAVSPTGANSWLNNMFGN--PQSSSLDP 184

  Fly   185 SFNWFDLDTYGGRLGHFVDQSMAW---INWHWRHEERHEAVYRKYFPKIADKRSL-SEITRNFAL 245
            | |:.............::..|:.   :.:::.|....::||..:|..:..:..| .::|:|.:|
  Fly   185 S-NFLPFTERMNTRQRILNSLMSTFERLTYNFFHLISQQSVYTNHFELLVKELPLYRDLTKNLSL 248

  Fly   246 ILVNQHFTMAPPRPYVPNIIEVGGMHVDQ-QPKALPQDLEDFIQGAGEHGVIYFSLGTNVRSRNL 309
            .|:|.|..:..||.|:||::||||:|:.. ....||:.|..|::.| ..||||||||.:|.:..|
  Fly   249 ALINSHPGLHYPRAYLPNMVEVGGLHLSHLNDDNLPKHLLSFMESA-PSGVIYFSLGADVETAQL 312

  Fly   310 SKDRRKILIDTFASLPQ-RILWKFDADELSD---VPSNVLISPWFPQQDILAHPNVKLFITHGGL 370
            .:::..|::|.|..|.: ..|.|::.:|.:.   :|.||:|:.|:|||.||.||.||:||:..|.
  Fly   313 PQEKLAIILDVFGHLKEFHFLLKWEKEEFTAEQVLPENVMIADWWPQQAILHHPQVKMFISSCGQ 377

  Fly   371 QSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKA 435
            .|..|.|....|:|.:|...:|....:.::..|:.:.:.|..:..|.....|.||....|:..|.
  Fly   378 LSVWESISGQKPVLAIPILAEQEVMAKRLQRHGVSVTVGYDSLAYDSLLHGIRQLTLNTSYVEKL 442

  Fly   436 KRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLAVWAILSI 500
            .:..:|...:...|:..|:.....:|...||..::.....|:|.....:|||....:..:.||:|
  Fly   443 GQLKERLISRDSTPVGKAVRKIQLILESGGADFLKSHANTLNFWRAEGVDVLLIIAVGFFGILTI 507

  Fly   501 VVLCAIKLLRAILKSKKGNISPKQKIN 527
            ..|....:||....|:.....|..:.|
  Fly   508 PFLAICFILRKSYHSQAAQDQPPYRTN 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	136/486 (28%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	126/442 (29%)
Ugt316A1	NP_001287111.1	egt	1..480	CDD:223071	138/491 (28%)
Ugt316A1	NP_001287111.1	MGT	39..448	CDD:273616	119/424 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445644
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	189	1.000	Inparanoid score	I2570
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D45181at50557
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.900