DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and Ugt1a3

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_958827.1	Gene:	Ugt1a3 / 396551	RGDID:	1549728	Length:	531	Species:	Rattus norvegicus

Alignment Length:	553	Identity:	153/553 - (27%)
Similarity:	273/553 - (49%)	Gaps:	76/553 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSP----FPLKEPVANI 71
            ::|::..|| ..||.::| |||:.. ||:......:::|.:.||:...::|    ...:|....:
  Rat    13 LLLLLCALP-WAEGGKVL-VFPMEG-SHWLSMRDVVRELHARGHQAVVLAPEVTVHIKEEDFFTL 74

  Fly    72 HDIPVPELFDNI-EEIVGNLTNRKGTWNEFEYINQYTLGLV------------------EKVLEN 117
            ...|||...:.. ..::|:|.      |.||  .:::|.||                  ..:|.|
  Rat    75 QTYPVPYTKEEYRHHLLGHLQ------NFFE--TEFSLKLVLQRMAAVNNVSTFYVRSCRGLLHN 131

  Fly   118 DGVRREILQPESLQFDLIIVD-LWRLDALYGLAAYFDAPIIGIASYGTDWKIDELVGNVSPLAYL 181
            ..:.:.:   .|..||:::.| .:...|:  ||.|...|.:....              |.|..|
  Rat   132 TALIQSL---NSSSFDVVLTDPFFPCGAV--LAMYLRVPAVFFLQ--------------SMLCEL 177

  Fly   182 QSPSFNWFDLDTYGGRL-----GH--FVD--QSMAW-INWHWRHEERHEAVYRKYFPKIADKRSL 236
            :..:.|..:..:|..||     .|  |:|  ::|.: :.|.:.....:.::.|.....:..:.|:
  Rat   178 EFEATNSPNPSSYIPRLLTLNSDHMSFLDRVKNMLYPVPWMYLCHVNYGSLARLASDLLQREVSV 242

  Fly   237 SEITRNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLG 301
            .||.|:.::.|:.:.|....|||::||::.:||::...: |.|.|:.|.::..:||||::.||||
  Rat   243 VEILRHASVWLLRKDFVFYYPRPFMPNMVFIGGINCANR-KPLSQEFEAYVNASGEHGIVVFSLG 306

  Fly   302 TNVRSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPNVKLFIT 366
            :.|  ..:.:.:...:.:....:||.:||::.....|::..|.::..|.||.|:|.||..:.|||
  Rat   307 SMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFIT 369

  Fly   367 HGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSF 431
            |.|.....|.|..||||:.:|.|.||..|.:.::.:|.|:.||..:||:|:.::.:..::..||:
  Rat   370 HSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSY 434

  Fly   432 GVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLAVWA 496
            .....|.:..::|:|:.|||.|::|..||:|||||||:|.|..:|.:..||||||:| ||||:
  Rat   435 KENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIG-FLLAI-- 496

  Fly   497 ILSIVVL----CAIKLLRAILKSKKGNISPKQK 525
            :|::|.:    ||....:..  ..||.:....|
  Rat   497 VLTVVFIVYKSCAYGCRKCF--GGKGRVKKSHK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	132/491 (27%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	111/447 (25%)
Ugt1a3	NP_958827.1	UDPGT	26..522	CDD:278624	147/532 (28%)
Ugt1a3	NP_958827.1	egt	<228..505	CDD:223071	98/282 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860