DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and Ugt1a2

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_958826.1	Gene:	Ugt1a2 / 396527	RGDID:	1549741	Length:	533	Species:	Rattus norvegicus

Alignment Length:	549	Identity:	154/549 - (28%)
Similarity:	276/549 - (50%)	Gaps:	68/549 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSP---FPLK-EPVANI 71
            ::|::..|| ..||.::| |||:.. ||:......:::|.:.||:...::|   ..:| |....:
  Rat    15 LLLLLCALP-WAEGGKVL-VFPMEG-SHWLSMRDVVRELHARGHQAVVLAPEVTVHMKGEDFFTL 76

  Fly    72 HDIPVPELFDNIE-EIVGNLTNRKGTWNEFE---YINQY--TLGLVEK-----------VLENDG 119
            .....|...:..: ||:||.  :||    ||   ::..:  |:..::|           :|.|
  Rat    77 QTYAFPYTKEEYQREILGNA--KKG----FEPQHFVKTFFETMASIKKFFDLYANSCAALLHN-- 133

  Fly   120 VRREILQPESLQFDLIIVD-LWRLDALYGLAAYFDAPIIGI---ASYGTDWKIDELVGNVSPLAY 180
             :..|.|..|..||:::.| ::...||  ||.|...|.:..   ...|.|::..:.   ..|.:|
  Rat   134 -KTLIQQLNSSSFDVVLTDPVFPCGAL--LAKYLQIPAVFFLRSVPCGIDYEATQC---PKPSSY 192

  Fly   181 LQSPSFNWFDLDTYGGRLGHFV-DQSMAWINWHWRHEERHEAV--YRKYFPKIADKR-SLSEITR 241
            :.:......|..|:..|:.:.: ..::.:|        .|.::  |.....::..:. ||.|:..
  Rat   193 IPNLLTMLSDHMTFLQRVKNMLYPLTLKYI--------CHLSITPYESLASELLQREMSLVEVLS 249

  Fly   242 NFALILVNQHFTMAPPRPYVPNIIEVGGMH-VDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVR 305
            :.::.|....|....|||.:||::.:||:: |.::|  |.|:.|.::..:||||::.||||:.|
  Rat   250 HASVWLFRGDFVFDYPRPIMPNMVFIGGINCVIKKP--LSQEFEAYVNASGEHGIVVFSLGSMV- 311

  Fly   306 SRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPNVKLFITHGGL 370
             ..:.:.:...:.:....:||.:||::.....|::..|.::..|.||.|:|.||..:.||||.|.
  Rat   312 -SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGS 375

  Fly   371 QSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKA 435
            ....|.|..||||:.:|.|.||..|.:.::.:|.|:.||..:||:|:.::.:..::..||:....
  Rat   376 HGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENI 440

  Fly   436 KRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLAVWAILSI 500
            .|.:..::|:|:.|||.|::|..||:|||||||:|.|..:|.:..||||||:| ||||:  :|::
  Rat   441 MRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIG-FLLAI--VLTV 502

  Fly   501 VVL----CAIKLLRAILKSKKGNISPKQK 525
            |.:    ||....:..  ..||.:....|
  Rat   503 VFIVYKSCAYGCRKCF--GGKGRVKKSHK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	133/487 (27%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	112/443 (25%)
Ugt1a2	NP_958826.1	UDPGT	28..524	CDD:278624	148/528 (28%)
Ugt1a2	NP_958826.1	egt	<261..507	CDD:223071	92/252 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860