DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and Ugt1a1

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_964007.2	Gene:	Ugt1a1 / 394436	MGIID:	98898	Length:	535	Species:	Mus musculus

Alignment Length:	571	Identity:	157/571 - (27%)
Similarity:	272/571 - (47%)	Gaps:	102/571 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RLIVLVVALL-----PVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSPFPLKEPV 68
            ||::|:..||     |......|:| |||:.. ||:...|..:::|...|||:..::      |.
Mouse     9 RLLLLLPYLLLCVFGPSASHAGRLL-VFPMDG-SHWLSMLGVIQQLQQKGHEVVVIA------PE 65

  Fly    69 ANIH----------DIPVPELFDNIEEIVGNLTNRKGTWNEFEYINQYTLGLVEKVLENDGVRRE 123
            |:||          ..|||...:|:...:..|  .:..:|:    :.:.|.:|:..::   |:|:
Mouse    66 ASIHIKEGSFYTLRKFPVPFQKENVTATLVEL--GRTAFNQ----DSFLLRVVKIYMK---VKRD 121

  Fly   124 -----------------ILQPESLQFDLIIVDLWRLDALYGLAAYFDAPII--------GIASYG 163
                             :...|...||.::.|.: |.....:|.|...|.:        .:.|..
Mouse   122 SSMLLAGCSHLLHNAEFMASLEESHFDALLTDPF-LPCGSIVAQYLTVPTVYFLNKLPCSLDSEA 185

  Fly   164 TDWKIDELVGNVSPLAYL-QSPSFNWFDLDTYGGRLGHFVDQSMAWI-----NWHWRHEERHEAV 222
            |...:        ||:|: :|.|||       ..|: :|:.:....:     |:..|      .|
Mouse   186 TQCPV--------PLSYVPKSLSFN-------SDRM-NFLQRVKNVLLAVSENFMCR------VV 228

  Fly   223 YRKY---FPKIADKR-SLSEITRNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDL 283
            |..|   ..:|..|. ::.::....::.|:...|....|||.:||::.:||::. .|.|.|.|:.
Mouse   229 YSPYGSLATEILQKEVTVQDLLSPASIWLMRSDFVKDYPRPIMPNMVFIGGINC-LQKKPLSQEF 292

  Fly   284 EDFIQGAGEHGVIYFSLGTNVRSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISP 348
            |.::..:||||::.||||:.|  ..:.:.:...:.:....:||.:||::.....|::..|.::..
Mouse   293 EAYVNASGEHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVK 355

  Fly   349 WFPQQDILAHPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDM 413
            |.||.|:|.||..:.||||.|.....|.|..||||:.:|.|.||..|.:.::.:|.|:.||..:|
Mouse   356 WLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEM 420

  Fly   414 TSDEFKDTIHQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDF 478
            |:|:.::.:..::..||:.....|.:..::|:|:.|||.|::|..||:|||||||:|.|..:|.:
Mouse   421 TADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTW 485

  Fly   479 ITYHSLDVLGTFLLAVWAILSIVVL----CAIKLLRAILKSKKGNISPKQK 525
            ..||||||:| ||||:  :|::|.:    ||....:..  ..||.:....|
Mouse   486 YQYHSLDVIG-FLLAI--VLTVVFIVFKCCAYGCRKCF--GGKGRVKKSHK 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	133/502 (26%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	114/458 (25%)
Ugt1a1	NP_964007.2	egt	20..507	CDD:223071	147/532 (28%)
Ugt1a1	NP_964007.2	UDPGT	30..526	CDD:278624	150/543 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840304
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690