DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E2 and Ugt1a9

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_964006.2	Gene:	Ugt1a9 / 394434	MGIID:	3576092	Length:	528	Species:	Mus musculus

Alignment Length:	559	Identity:	158/559 - (28%)
Similarity:	266/559 - (47%)	Gaps:	92/559 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSP---FPL-KEPVANIHD 73
            |.:.|...|.:..|:| |.|:.. ||::.....::||...|||:..|.|   :.| |.....:..
Mouse    12 LCLLLASGLAQAGRLL-VVPMDG-SHWFTMQMVVEKLIHRGHEVVVVIPEVSWQLGKSLNCTVKT 74

  Fly    74 IPVPELFDNIEEIVGNLTNRKGTWNEFEYINQYT-----------------LGLVE------KVL 115
            ..:....::::             .||:|:: ||                 .|..|      :.|
Mouse    75 YSISHTLEDLD-------------REFKYLS-YTQWKTPEHSIRSFLTGSARGFFELTFSHCRSL 125

  Fly   116 ENDGVRREILQPESLQFDLIIVDLWRLDALYGLAAYFDAPIIGIASYGT--DWKIDELVGNVSPL 178
            .||....|.|:...  ||.:.:|.:.:..|. :|.||..|.: |.:.|.  |: ::|
Mouse   126 FNDKKLVEYLKQRF--FDAVFLDPFDVCGLI-VAKYFSLPSV-IFARGVFCDY-LEE-------- 177

  Fly   179 AYLQSPSFNWFDLDTYGGRLGHFVDQSMAWINWHWRH---EERHEAVYRKYFPKIADKRSLSEIT 240
             ..|.||     |.:|..||......:|.:....|.|   .|.|  .:..||.:.|.:.: |||.
Mouse   178 -GAQCPS-----LPSYVPRLFSKYTDTMTFKERVWNHLIYIEEH--AFCSYFLRTAVEVA-SEIL 233

  Fly   241 RN----------FALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGV 295
            :.          .::.|:...|.:..|||.:||::.:||::. .|.|:|.::.|.::..:||||:
Mouse   234 QTPVTMTDLFSPVSIWLLRTDFVLEFPRPVMPNMVFIGGINC-LQKKSLSKEFEAYVNASGEHGI 297

  Fly   296 IYFSLGTNVRSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPN 360
            :.||||:.|  ..:.:.:...:.:....:||.:||::.....|::..|.::..|.||.|:|.||.
Mouse   298 VVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPK 360

  Fly   361 VKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQL 425
            .:.||||.|.....|.|..||||:.:|.|.||..|.:.::.:|.|:.||..:||:|:.::.:..:
Mouse   361 TRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTV 425

  Fly   426 LTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTF 490
            :..||:.....|.:..::|:|:.|||.|::|..||:|||||||:|.|..:|.:..||||||:| |
Mouse   426 INNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIG-F 489

  Fly   491 LLAVWAILSIVVL----CAIKLLRAILKSKKGNISPKQK 525
            |||:  :|::|.:    ||....:..  ..||.:....|
Mouse   490 LLAI--VLTVVFIVFKCCAYGCRKCF--GGKGRVKKSHK 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	137/499 (27%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	118/455 (26%)
Ugt1a9	NP_964006.2	egt	9..500	CDD:223071	153/531 (29%)
Ugt1a9	NP_964006.2	UDPGT	24..519	CDD:278624	154/540 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840328
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690