DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E2 and Ugt1a5

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_964005.2	Gene:	Ugt1a5 / 394433	MGIID:	3032634	Length:	529	Species:	Mus musculus

Alignment Length:	565	Identity:	160/565 - (28%)
Similarity:	277/565 - (49%)	Gaps:	84/565 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPMSMLVLRLIVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSP---F 62
            ||:..||   .:|::..|| ..||.::| |||: ..||:......:::|.:.||:...::|   .
Mouse     5 MPLQGLV---GLLLLCALP-WTEGEKVL-VFPV-GGSHWLSMRDVVRELHAQGHQTVVLAPEVNM 63

  Fly    63 PLKEP---VANIHDIPVPELFDNIEEIVGNLTNRKGTWNEFEYI--------NQYT--LGLVEKV 114
            .:||.   ...::.:|...  ..:||::.||.....|.|..:.|        |..|  |.....:
Mouse    64 RIKEEDFFTFKVYAVPYTR--QELEEMMENLKVFFDTGNYMKKIFKTSEALRNMSTVLLKTCTNI 126

  Fly   115 LENDGVRREILQPESLQFDLIIVD-LWRLDALYGLAAYFDAPIIGIASY---GTDWKIDELVGNV 175
            |.|:.:...:   .|..||::..| ::...||  ||.|...|.:....|   |.:::..:.   .
Mouse   127 LHNESLLHHL---NSSSFDVVFTDPVFPCGAL--LAKYLGIPAVFFLRYIPCGIEYEATQC---P 183

  Fly   176 SPLAYLQSPSFNWFDLDTYGGRLGHFVD--QSMAWINWHWRHEERHEAVYRKY--------FPKI 230
            ||.:|:.    |.|.      ||...:|  |.:..:.:|         :..||        :..:
Mouse   184 SPSSYIP----NLFT------RLSDHMDFLQRVQNMLYH---------LVLKYICHLLITPYESL 229

  Fly   231 ADKRSLSEITR----NFALI-LVNQHFTMAPPRPYVPNIIEVGGMH-VDQQPKALPQDLEDFIQG 289
            |.:....|::.    ::|.: |....|.:..|||.:||::.:||:: |.::|  |.|:.|.::..
Mouse   230 ASELFQREVSSVELFSYASVWLFRGDFVLDYPRPIMPNMVFIGGINCVTKKP--LSQEFEAYVNA 292

  Fly   290 AGEHGVIYFSLGTNVRSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQD 354
            :||||::.||||:.|  ..:.:.:...:.:....:||.:||::.....|::..|.::..|.||.|
Mouse   293 SGEHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQND 355

  Fly   355 ILAHPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFK 419
            :|.||..:.||||.|.....|.|..||||:.:|.|.||..|.:.::.:|.|:.||..:||:|:.:
Mouse   356 LLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLE 420

  Fly   420 DTIHQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSL 484
            :.:..::..||:.....|.:..::|:|:.|||.|::|..||:|||||||:|.|..:|.:..||||
Mouse   421 NALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSL 485

  Fly   485 DVLGTFLLAVWAILSIVVL----CAIKLLRAILKSKKGNISPKQK 525
            ||:| ||||:  :|::|.:    ||....:..  ..||.:....|
Mouse   486 DVIG-FLLAI--VLTVVFIVFKCCAYGCRKCF--GGKGRVKKSHK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	135/493 (27%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	114/449 (25%)
Ugt1a5	NP_964005.2	UDPGT	26..520	CDD:278624	150/533 (28%)
Ugt1a5	NP_964005.2	egt	<257..501	CDD:223071	92/250 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840617
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690