DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and Ugt1a7c

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_964004.1	Gene:	Ugt1a7c / 394432	MGIID:	3032636	Length:	531	Species:	Mus musculus

Alignment Length:	552	Identity:	156/552 - (28%)
Similarity:	267/552 - (48%)	Gaps:	75/552 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LVVALLPV--LLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSP---FPLKEPVANIH 72
            |.|.||..  |.:..|:| |.|:.. ||::.....::||...|||:..|.|   :.|.:|:..:
Mouse    12 LCVCLLLASGLAQAGRLL-VVPMDG-SHWFTMQTVVEKLLHKGHEVVVVVPEVSWQLTKPLNFV- 73

  Fly    73 DIPVPELFDNIEEIVGNLTNRK------GTWNE------FEYINQYTLGLVE------KVLENDG 119
             :....:....|::     ||:      ..|..      ...::....|..|      :.|.||.
Mouse    74 -VKTYAVSHTQEDL-----NREFKIFIDAQWKSQQEGGILPLLDSPAKGFFELLFSHCRSLFNDK 132

  Fly   120 VRREILQPESLQFDLIIVDLWRLDALYGLAAYFDAPII----GIASYGTDWKIDELVGNVSPLAY 180
            ...|.|:..|  ||.:.:|.:.:..| .:|.||..|.:    ||..:    .:::.....||.:|
Mouse   133 KLVEYLKQTS--FDAVFLDPFDVCGL-TVAKYFSLPSVVFSRGIFCH----YLEDAAQCPSPPSY 190

  Fly   181 LQSPSFNWFDLDTYGGRLGHFVDQSMAWINWHWRHEERHEAVYRKYFPKIADKRS--------LS 237
            :......:.|..|:..|..:.    :|::.      ||  |...|:|...||..|        ::
Mouse   191 IPRMLLKFTDTMTFKERTRNL----LAYMG------ER--AFCHKFFKSAADIASEVLQTPVTMT 243

  Fly   238 EITRNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGT 302
            ::....::.|:...|.:..|||.:||:|.:||::. .|.|.|.::.|.::..:||||::.||||:
Mouse   244 DLFSPVSIWLLRTDFVLEFPRPVMPNVIYIGGINC-HQGKPLSKEFEAYVNASGEHGIVVFSLGS 307

  Fly   303 NVRSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPNVKLFITH 367
            .|  ..:.:.:...:.:....:||.:||::.....|::..|.::..|.||.|:|.||..:.||||
Mouse   308 MV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITH 370

  Fly   368 GGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFG 432
            .|.....|.|..||||:.:|.|.||..|.:.::.:|.|:.||..:||:|:.::.:..::..||:.
Mouse   371 SGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYK 435

  Fly   433 VKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLAVWAI 497
            ....|.:..::|:|:.|||.|::|..||:|||||||:|.|..:|.:..||||||:| ||||:  :
Mouse   436 ENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIG-FLLAI--V 497

  Fly   498 LSIVVL----CAIKLLRAILKSKKGNISPKQK 525
            |::|.:    ||....:..  ..||.:....|
Mouse   498 LTVVFIVFKCCAYGCRKCF--GGKGRVKKSHK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	133/490 (27%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	114/446 (26%)
Ugt1a7c	NP_964004.1	UDPGT	26..522	CDD:278624	150/531 (28%)
Ugt1a7c	NP_964004.1	egt	<225..503	CDD:223071	98/283 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840664
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690