DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and Ugt49C1

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	161/525 - (30%)
Similarity:	290/525 - (55%)	Gaps:	37/525 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSPFPL-KEPV-ANIHDIPVPELFDNI 83
            |.||::||.|:..|..||:......:::|...||::|.|:.|.| ||.: :|..:|.:..::|..
  Fly    21 LAEGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAFSLEKEQLGSNYTEILIEPVYDFW 85

  Fly    84 EEIVGNLTNRKGTWNEFEYINQYTLGLVEKVLENDGVR-----------REILQPESLQ--FDLI 135
            .::..|.    |..:.||.........: |:||..|::           |.::..|..:  |||:
  Fly    86 HDVKLNF----GAQHLFELTRMTNYDFL-KMLEIIGLKTTEHALRQPKVRSLIHAEQKEGVFDLL 145

  Fly   136 IVDLWRLDALYGLAAYFDAPIIGIASYGTDWKIDELVGNVSPLAYLQSPSFNWFD----LDTYGG 196
            :.:.:..:|...||..:..|::..::.|.:..:.:::|.::|.:::......:.|    |:....
  Fly   146 LAEQFYQEAFLALAHLYKIPVVTTSTLGYENHMSQMMGLITPWSFVPHGFMPFTDRMSFLERVKN 210

  Fly   197 RLGHFVDQSMAWINWHWRHEERHEAVYRKYF-PKIADKRSLSEITRNFALILVNQHFTMAPPRPY 260
            ....|.:.....:|:.    .:.:||.|::| |.:.:...:..:.|..:::|:|.|..:...||.
  Fly   211 SYASFYEDMDRLLNYF----PKMDAVAREFFGPVLTEVPKVKHMERQISVMLLNSHAPLTTARPT 271

  Fly   261 VPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVRSRNLSKDRRKILIDTFASLP 325
            |..::.|||||: ..||.||.|::..:.||.| |.|:||||:||:|:::..:..::.:..|.||.
  Fly   272 VDAMVPVGGMHI-YPPKPLPADMQALLDGATE-GAIFFSLGSNVQSKDMPVEMLRLFLQVFGSLK 334

  Fly   326 QRILWKFDADELSDVPSNVLISPWFPQQDILAHPNVKLFITHGGLQSTVECIHRGVPMLGLPFFY 390
            ||:||||:.:.:|.:|.||::..|.||.|||||.:||:|||||||..|.|.:|..|||||:||:.
  Fly   335 QRVLWKFEDESISQLPDNVMVRKWLPQADILAHRHVKVFITHGGLFGTQEGVHYAVPMLGIPFYC 399

  Fly   391 DQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIW 455
            ||..||......|..:.|:::.:|.:..:.::.||:...::....:|.:|.:||:|:.|..:|::
  Fly   400 DQHLNMNKAVLGGYAISLHFQSITEEILRHSLDQLIHNVTYKENVQRVSDIFRDRPLEPRKSAVY 464

  Fly   456 WTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLAVWAILSIVVLCAIKL-LRAILKSKKGN 519
            |..||:||:||.|||.||.:|::..::.|||     :|..||:::..:.|:.| :|.::.|.|.:
  Fly   465 WIEYVIRHRGASHMRSAGLDLNWFQFYLLDV-----IAFVAIIALAGVMALSLAIRLLMGSNKKH 524

  Fly   520 ISPKQ 524
            ...||
  Fly   525 RKAKQ 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	147/477 (31%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	126/433 (29%)
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	153/497 (31%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	144/476 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454699
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	10	9.790