DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E2 and Ugt49B1

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	183/536 - (34%)
Similarity:	300/536 - (55%)	Gaps:	20/536 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SMLVLRLIVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSPFPL-KEP 67
            |.|.:.|:.||......|..|:|||..|..|..||:......:::|...|||:|.::||.| ||.
  Fly     5 SALHIFLLSLVALQQLELGTGSRILAAFFFPGKSHFMMTNAIIRELVKQGHEVTFITPFSLAKEK 69

  Fly    68 V-ANIHDIPVPELFDNIEEIVGNLTNRK--------GTWNEFEYINQYTLGLVEKVLENDGVRRE 123
            : :|..:|.:|: :|...|| ..:||:.        .|:.....:|...:...:..||...::..
  Fly    70 LGSNYKEIVIPQ-YDFWPEI-KEMTNKNTVLEMTDLPTFAFLRMVNVMGIHTTDFALEQPEIQAV 132

  Fly   124 ILQPESL-QFDLIIVDLWRLDALYGLAAYFDAPIIGIASYGTDWKIDELVGNVSPLAYLQSPSFN 187
            |.:...: ::||::.:.:..:....|...:..|.|.|:::|....:.:|.|.|||.:|:......
  Fly   133 INEKNKIGKYDLLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLFGVVSPWSYVPHAYMP 197

  Fly   188 WFDLDTYGGRLGHFVDQSMAWINWHWRHEERHEAVYRKYFPKIADK-RSLSEITRNFALILVNQH 251
            :.|..|...|:|:....:...:...:.:....:||.:|:|.|:.|: .::.|:.||.:.||:|.:
  Fly   198 YTDRMTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLDRVPTIKELERNISAILLNSY 262

  Fly   252 FTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVRSRNLSKDRRKI 316
            ..:|..||...|:|.|||:|: |.|||||:.|:.|:.|| .||.||||||:.|||.:|..::.|:
  Fly   263 MPLASSRPMAYNMIPVGGLHI-QPPKALPEHLQKFLDGA-THGAIYFSLGSQVRSADLPPEKLKV 325

  Fly   317 LIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPNVKLFITHGGLQSTVECIHRGV 381
            .::.|.||.||:||||:.:.|.::|:||.:..|.||.|||||||||:||.||||..|.|.::.||
  Fly   326 FLEVFGSLKQRVLWKFEDESLPNLPANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGV 390

  Fly   382 PMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKRTADRYRDQP 446
            |:||:|.:.||.:|:...|:....|.|:||.:|.:|.:..:.:|:....:....|:.:..:||:|
  Fly   391 PILGMPVYCDQHQNINQGKSAEYALGLDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRP 455

  Fly   447 MNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLAVWAILSIVVLCAIKLLRA 511
            :..:||||:|.:||:.|:||||:..||.:|.:..::.||::|..|..:  :|.||||  |.:.|.
  Fly   456 LGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGLGLAVI--LLPIVVL--ILICRR 516

  Fly   512 ILKSKKGNISPKQKIN 527
            ..|.|......|.|.|
  Fly   517 SSKPKSTPTKKKTKKN 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	161/469 (34%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	142/425 (33%)
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	176/513 (34%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	165/484 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454700
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	10	9.790