DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E2 and Ugt36E1

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	170/549 - (30%)
Similarity:	281/549 - (51%)	Gaps:	72/549 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IVLVVALLPVLL--EGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSPFPLKEPVANIHD 73
            :..::|||.::.  :..||||:||.|:.||:....|.::.||..||.:..:|||..|:|.....|
  Fly     7 VFCLLALLSLVAFSDSLRILGLFPHPAISHFKFFHPIMRGLAEAGHSVDVISPFEDKDPPNGYKD 71

  Fly    74 --IPVPELFDNIEEIVGNLTNRKGTWNEFEYINQYTLGLVE-KVLENDG-----------VRREI 124
              :|...|.|.|            :..:||....:....|| .:|...|           ...||
  Fly    72 HLLPPSTLTDTI------------SLEDFERPYSFLFHYVEFFILHKMGREDCNTTLHSRALTEI 124

  Fly   125 LQPESLQFDLIIVDLWRLDALYGLAAYFDAPIIGIASYG-TDWKIDE-----LVGNVSPLAYLQS 183
            |:.....:|:|:::.:..|....:|..|.||:||::|.. ..|..:.     :...:|.|...||
  Fly   125 LKNPPGYYDVILLEQFNTDCAMSVAHVFQAPVIGMSSCALMPWHYERFGAPLIPSYISALFQGQS 189

  Fly   184 PSFNWFDLDTYGGRLGHFVDQSMAWINWH--------WRHEERHEAVYRKYFPKIADKRSLSEIT 240
            ...      ::.||||:       ||..|        :.....:..:.:::.|.:.   |..::.
  Fly   190 QEM------SFAGRLGN-------WITVHSLNLLYKMFTVPAGNALIRQRFGPGLP---STEDLV 238

  Fly   241 RNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVR 305
            ||.:|:||||||:::.|:|..||:|||||:|: ..||.||.||:..:..|.: |||..|.|:.::
  Fly   239 RNTSLMLVNQHFSLSGPKPLPPNVIEVGGVHI-SPPKPLPSDLQKILDNAPK-GVILISWGSQLK 301

  Fly   306 SRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPNVKLFITHGGL 370
            :.:||..||..::.....|.|.::||::.|.|.:.|.|:.|..|.||:|||||||:|:|::||||
  Fly   302 ACSLSAARRDGIVKAIGRLEQEVIWKYENDTLPNKPPNLHIRKWLPQRDILAHPNLKVFMSHGGL 366

  Fly   371 QSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLT---EKSFG 432
            ..|.|.:...||::|:|.:.||..|:..:..:|:.|.|..:.:  ||  :|:::.||   :.||.
  Fly   367 MGTTEAVSSAVPIVGVPIYGDQSLNIAALVQRGMALQLELKKL--DE--NTVYEALTKALDPSFK 427

  Fly   433 VKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLAVWAI 497
            .:||..|..|.::...||:|||||..:|...||||..:.:..:|....|:||||.....|::  :
  Fly   428 ARAKEVASSYNNRIQGPLETAIWWVEHVAETKGAPLTQPSAVHLSRFVYYSLDVYSVVALSL--L 490

  Fly   498 LSIVVLCAIKLLRAILKSK-KGNISPKQK 525
            |.::.|  :.|:|...:.: ||:...|:|
  Fly   491 LPVITL--LGLIRMFKRREPKGDRKLKRK 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	153/488 (31%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	138/444 (31%)
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	151/486 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454614
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.890