DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and Ugt301D1

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	516	Identity:	168/516 - (32%)
Similarity:	279/516 - (54%)	Gaps:	55/516 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LIVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSPFPLKEPVANIHDI 74
            :::.::.||. ...|:|||.:.|.|:.||:.....:...|...||.:|||:..|.|.|..|:.:|
  Fly    11 MLIFLIGLLE-FGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVTSVNNHPTKHPHENLTEI 74

  Fly    75 PVPELFD--------NI--EEIVGNLTNRKGTWNEFEYINQYTLGLV--EKVLENDGVRREILQP 127
            .:...||        ||  .:.|.:..|.:..|         |:||:  |...::..|:: :::.
  Fly    75 IISPSFDIPKHFPKENIFSMQFVSDFNNLELWW---------TIGLMTTEHAFKDPKVKK-LIES 129

  Fly   128 ESLQFDLIIVDLWRLDALYGLAAYFDAPIIGIASYGTDWKIDELVGNVSPLAYLQSPSFNWFDLD 192
            :...:||:|::.:..:|.......|:.|::.|.:.|....||..:|.::|.:.:.....:..|..
  Fly   130 KDDHYDLVIIEQFFHEAFLMFGKRFNCPVVTIGTMGYADNIDHAMGILTPWSLIPHLLLSHTDRM 194

  Fly   193 TYGGRLGHFVDQSMAWINWH------WRHEERHEAVYRKYF--------PKIADKRSLSEITRNF 243
            |:|.|..:      |:::.:      |.:..:.:.:..|||        |.:.|      :.||.
  Fly   195 TFGQRAYN------AYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGPLPNVLD------LERNI 247

  Fly   244 ALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVRSRN 308
            :|:|:|.|.::..|||.:|.:|:|||.|: |:||.||.||::|:..| .:||||||:|:.|:|.:
  Fly   248 SLVLINAHRSIDLPRPSMPGLIDVGGAHI-QKPKQLPTDLQNFLDNA-TYGVIYFSMGSYVKSTD 310

  Fly   309 LSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPNVKLFITHGGLQST 373
            |.:::..:::..|..|.|:::|||:.|.:.|:||||:|..|.||.||||||||||||||||:..|
  Fly   311 LPQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHPNVKLFITHGGIFGT 375

  Fly   374 VECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKRT 438
            .|.|:.|||||.:|.:.||.||......:|....|.:..:|:|:....|..|:.:..:...|...
  Fly   376 QEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLINDPQYKRSALEV 440

  Fly   439 ADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFL----LAVW 495
            :.|:||.|::|||.|.:|..|::||:||.|::..|..:....|..|||||..|    ||:|
  Fly   441 SQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCLLLGAFLAIW 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	156/483 (32%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	139/439 (32%)
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	158/495 (32%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	150/469 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.860