DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and Ugt2b37

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001007265.4	Gene:	Ugt2b37 / 29623	RGDID:	3937	Length:	530	Species:	Rattus norvegicus

Alignment Length:	551	Identity:	153/551 - (27%)
Similarity:	263/551 - (47%)	Gaps:	71/551 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VLRLIVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSPF------PLK 65
            :..|::|.::......:..::| |:|: ..||:.:....|.:|...|||:|.:.|.      |.|
  Rat     6 IFALLLLQISFCLRSAKCGKVL-VWPM-EFSHWMNIKTILDELVQRGHEVTVLKPSAYYVLDPKK 68

  Fly    66 EPVANIHDIPVPELFDNIEEIVGNLTNRKGTW-----------------NEFEYINQYTLGLVEK 113
            .|.......|.....|.:|:....|.:   .|                 |..:..:.|.|.:.:.
  Rat    69 SPDLKFETFPTSVSKDELEKYFIKLVD---AWTYELQRDTCLSFSPLLQNMMDEFSDYYLSVCKD 130

  Fly   114 VLENDGVRREILQPESLQFDL-----------IIVDLWRLDALYGLAAYFDAPIIGIASYGTDWK 167
            .:.|..:..::   :..:||:           :|.::..:..||.|.|            ....|
  Rat   131 AVSNKQLMAKL---QESKFDVLLSDPVAACGELIAEVLHIPFLYSLRA------------SPGHK 180

  Fly   168 IDELVGNVSPLAYLQSPSFNWFDLDTYGGRLGHFVDQ-----SMAWINWHWRHEERHEAVYRKYF 227
            |::..|.     ::..||:....|...||:: .|:|:     .|.:.:: |.|....:.....|.
  Rat   181 IEKSSGR-----FILPPSYVPVILSGLGGQM-TFIDRVKNMICMLYFDF-WFHMFNAKNWDPFYT 238

  Fly   228 PKIADKRSLSEITRNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGE 292
            ..:....:|:|......:.|:..::.:..|.|.:||:..:||:.. :..|.||:|:|||:|.:||
  Rat   239 EILGRPTTLAETMGKAEMWLIRSYWDLEFPHPTLPNVDYIGGLQC-KPAKPLPKDIEDFVQSSGE 302

  Fly   293 HGVIYFSLGTNVRSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILA 357
            |||:.||||:.|.|  :::::...:....|.:||::|||||....:.:..|..:..|.||.|:|.
  Rat   303 HGVVVFSLGSMVSS--MTEEKANAVAWALAQIPQKVLWKFDGKIPATLGPNTRVYKWLPQNDLLG 365

  Fly   358 HPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTI 422
            ||..|.|:||||.....|.|:.|:||:|:|.|.:|..|:.|:.|:|..:.||.|.|:..:..:.:
  Rat   366 HPKTKAFVTHGGANGVYEAIYHGIPMIGIPMFGEQHDNIAHMVAKGAAVTLNIRTMSKSDLFNAL 430

  Fly   423 HQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVL 487
            .:::....:...|...:..:.||||.|||.||:|..||:|||.|.|:|..|.||.:..||||||:
  Rat   431 KEVINNPFYKKNAMWLSTIHHDQPMKPLDKAIFWIEYVMRHKRAKHLRPLGHNLPWYQYHSLDVI 495

  Fly   488 GTFLLAVWAIL-SIVVLCAIKLLRAILKSKK 517
            | ||||..|:: ::.|.|.:.:.|...|.:|
  Rat   496 G-FLLACLAVIAALAVKCFLFIYRFFAKKQK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	134/496 (27%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	113/452 (25%)
Ugt2b37	NP_001007265.4	UDPGT	24..527	CDD:278624	151/533 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.760