DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and Ugt2b17

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_775417.1	Gene:	Ugt2b17 / 286954	RGDID:	708541	Length:	529	Species:	Rattus norvegicus

Alignment Length:	543	Identity:	150/543 - (27%)
Similarity:	273/543 - (50%)	Gaps:	50/543 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IVLVVALLPVLLEGA--RILGVFPIPSHSHYYHALPYLKKLASLGHEIT------SVSPFPLKEP 67
            :.|::.|:.....||  ::| |:| ..:||:.:....|.:||..|||:|      |:...|.||.
  Rat     8 VFLLIQLICYFRPGACGKVL-VWP-TEYSHWINIKIILNELAQRGHEVTVLVSSASILIEPTKES 70

  Fly    68 VANIHDIPVPELFDNIEEIVGNLTNRKGTW-NEFEYINQYT-LGLVEKVLEN-----DGVRREIL 125
            ..|.....||....::|.......:.   | .:||.::.:| ...::||...     :.:.:.::
  Rat    71 SINFEIYSVPLSKSDLEYSFAKWIDE---WTRDFETLSIWTYYSKMQKVFNEYSDVVENLCKALI 132

  Fly   126 QPESL-------QFDLIIVDLWRLDALYG-----LAAYFDAPIIGIASYGTDWKIDELVGNVS-P 177
            ..:||       |||:|:.|      ..|     ||.....|::....:...::.::..|.:. |
  Rat   133 WNKSLMKKLQGSQFDVILAD------AVGPCGELLAELLKTPLVYSLRFCPGYRCEKFSGGLPLP 191

  Fly   178 LAYLQSPSFNWFDLDTYGGRLGHFVDQSMAWINWHWRHEERHEAVYRKYFPKIADKRSLSEITRN 242
            .:|:........|..|:..|:.:.: |.:.:..|....:|:..:.:  |...:....:|:|:...
  Rat   192 PSYVPVVLSELSDRMTFVERVKNML-QMLYFDFWFQPFKEKSWSQF--YSDVLGRPTTLTEMMGK 253

  Fly   243 FALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVRSR 307
            ..:.|:...:.:..|.|::||...|||:|. :..|.||:::|:|:|.:|||||:.||||:.|  :
  Rat   254 ADIWLIRTFWDLEFPHPFLPNFDFVGGLHC-KPAKPLPREMEEFVQSSGEHGVVVFSLGSMV--K 315

  Fly   308 NLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPNVKLFITHGGLQS 372
            ||::::..::....|.:||:::|:||..:...:.||..:..|.||.|:|.||..|.|:.|||...
  Rat   316 NLTEEKANVVASALAQIPQKVVWRFDGKKPDTLGSNTRLYKWIPQNDLLGHPKTKAFVAHGGTNG 380

  Fly   373 TVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKR 437
            ..|.|:.|:|::|:|.|.||..|:.|:.|:|..:.:::..:::......:..::.:.|:...|.|
  Rat   381 IYEAIYHGIPIVGIPLFADQPDNINHMVAKGAAVRVDFSILSTTGLLTALKIVMNDPSYKENAMR 445

  Fly   438 TADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLAVWAILSIVV 502
            .:..:.|||:.|||.|::|..||:|||||.|:|....:|.:..||||||:|..||.|..::.|:.
  Rat   446 LSRIHHDQPVKPLDRAVFWIEYVMRHKGAKHLRSTLHDLSWFQYHSLDVIGFLLLCVVGVVFIIT 510

  Fly   503 LCAIKLLRAILKSKKGNISPKQK 525
            ...:...|     |..|:..|:|
  Rat   511 KFCLFCCR-----KTANMGKKKK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	132/485 (27%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	112/439 (26%)
Ugt2b17	NP_775417.1	UDPGT	24..527	CDD:278624	144/524 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.760