DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and Ugt2b15

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_695226.3	Gene:	Ugt2b15 / 266685	RGDID:	628623	Length:	530	Species:	Rattus norvegicus

Alignment Length:	521	Identity:	148/521 - (28%)
Similarity:	257/521 - (49%)	Gaps:	56/521 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VFPIPSHSHYYHALPYLKKLASLGHEITSVSPF------PLKEPVANIHDIPVPELFDNIEEIVG 88
            |:|: ..||:.:....|.:|...|||:|.:.|.      |.|.|.......|.....|.:|....
  Rat    28 VWPM-EFSHWMNIKTILDELVQRGHEVTVLKPSAYYVLDPKKSPDLKFETFPTSVSKDELENYFI 91

  Fly    89 NLTNRKGTW-----------------NEFEYINQYTLGLVEKVLENDGVRREILQPESLQFDLII 136
            .|.:   .|                 |..:..:.|.|.|.:..:.|..:..::   :..:||:::
  Rat    92 KLVD---VWTYELQRDTCLSYSPLLQNMIDGFSDYYLSLCKDTVSNKQLMAKL---QESKFDVLL 150

  Fly   137 VDLWRLDALYG--LAAYFDAPIIGIASYGTDWKIDELVGNVSPLAYLQSPSFNWFDLDTYGGRLG 199
            .|   ..|..|  :|.....|.:....:...:||::..|.     ::..||:....|...||.:
  Rat   151 SD---PVAACGELIAEVLHIPFLYSLRFSPGYKIEKSSGR-----FILPPSYVPVILSGMGGPM- 206

  Fly   200 HFVDQ------SMAWINW-HWRHEERHEAVYRKYFPKIADKRSLSEITRNFALILVNQHFTMAPP 257
            .|:|:      ::.:..| |..:.::.:..|.:.   :....:|:|......:.|:..::.:..|
  Rat   207 TFIDRVKNMICTLYFDFWFHMFNAKKWDPFYSEI---LGRPTTLAETMGKAEMWLIRSYWDLEFP 268

  Fly   258 RPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVRSRNLSKDRRKILIDTFA 322
            .|.:||:..:||:.. :.||.||:|:|||:|.:|||||:.||||:.|.|  :::::...:....|
  Rat   269 HPTLPNVDYIGGLQC-RPPKPLPKDMEDFVQSSGEHGVVVFSLGSMVSS--MTEEKANAIAWALA 330

  Fly   323 SLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPNVKLFITHGGLQSTVECIHRGVPMLGLP 387
            .:||::|||||....:.:..|..:..|.||.|:|.||..|.|:||||.....|.|:.|:||:|:|
  Rat   331 QIPQKVLWKFDGKTPATLGPNTRVYKWLPQNDLLGHPKTKAFVTHGGANGVYEAIYHGIPMVGIP 395

  Fly   388 FFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKRTADRYRDQPMNPLDT 452
            .|.:|..|:.|:.|:|..:.||.|.|:..:..:.:.:::....:...|...:..:.||||.|||.
  Rat   396 MFGEQHDNIAHMVAKGAAVTLNIRTMSKSDLFNALKEIINNPFYKKNAVWLSTIHHDQPMKPLDK 460

  Fly   453 AIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLAVWAILSIV-VLCAIKLLRAILKSK 516
            |::|..:|:|||||.|:|..|.||.:..||||||:| |||...|::::: |...:.:.|..:|.:
  Rat   461 AVFWIEFVMRHKGAKHLRPLGHNLPWYQYHSLDVIG-FLLTCSAVIAVLTVKSFLFIYRLFVKKE 524

  Fly   517 K 517
            |
  Rat   525 K 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	133/482 (28%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	113/441 (26%)
Ugt2b15	NP_695226.3	UDPGT	24..527	CDD:278624	148/521 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344063
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690