DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and Ugt1a1

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_036815.1	Gene:	Ugt1a1 / 24861	RGDID:	3935	Length:	535	Species:	Rattus norvegicus

Alignment Length:	557	Identity:	157/557 - (28%)
Similarity:	267/557 - (47%)	Gaps:	70/557 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SMLVLRLIVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSPFPLKEPV 68
            |:|:|..::|.| |.|......::| |.||.. ||:...|..:::|...|||:..::      |.
  Rat    10 SLLLLPCLLLCV-LGPSASHAGKLL-VIPIDG-SHWLSMLGVIQQLQQKGHEVVVIA------PE 65

  Fly    69 ANIH----------DIPVPELFDNIEEI---VGN--------LTNRKGTWNEFEYINQYTLGLVE 112
            |:||          ..|||...:|:...   :|.        |.....|:|:.:..:...|....
  Rat    66 ASIHIKEGSFYTMRKYPVPFQNENVTAAFVELGRSVFDQDPFLLRVVKTYNKVKRDSSMLLSGCS 130

  Fly   113 KVLENDGVRREILQPESLQFDLIIVDLWRLDALYGLAAYFDAPIIGIASYGTDWKID-ELVGNVS 176
            .:|.|......:   |...||.::.|.: |.....:|.|...|.:...: .....:| |.....:
  Rat   131 HLLHNAEFMASL---EQSHFDALLTDPF-LPCGSIVAQYLSLPAVYFLN-ALPCSLDLEATQCPA 190

  Fly   177 PLAYLQSPSFNWFDLDTYGGRLGHFVDQSMAWI-----NWHWRHEERHEAVYRKY---FPKIADK 233
            ||:|:..      .|.:...|: :|:.:....|     |:..|      .||..|   ..:|..|
  Rat   191 PLSYVPK------SLSSNTDRM-NFLQRVKNMIIALTENFLCR------VVYSPYGSLATEILQK 242

  Fly   234 R-SLSEITRNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIY 297
            . ::.::....::.|:...|....|||.:||::.:||::. .|.|||.|:.|.::..:||||::.
  Rat   243 EVTVKDLLSPASIWLMRNDFVKDYPRPIMPNMVFIGGINC-LQKKALSQEFEAYVNASGEHGIVV 306

  Fly   298 FSLGTNVRSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPNVK 362
            ||||:.|  ..:.:.:...:.:....:||.:||::.....|::..|.::..|.||.|:|.||..:
  Rat   307 FSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKAR 369

  Fly   363 LFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLT 427
            .||||.|.....|.|..||||:.:|.|.||..|.:.::.:|.|:.||..:||:|:.::.:..::.
  Rat   370 AFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVIN 434

  Fly   428 EKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLL 492
            .||:.....|.:..::|:|:.|||.|::|..||:|||||||:|.|..:|.:..||||||:| |||
  Rat   435 NKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIG-FLL 498

  Fly   493 AVWAILSIVVL----CAIKLLRAILKSKKGNISPKQK 525
            |:  :|::|.:    ||....:..  ..||.:....|
  Rat   499 AI--VLTVVFIVYKSCAYGCRKCF--GGKGRVKKSHK 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	132/488 (27%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	113/444 (25%)
Ugt1a1	NP_036815.1	UDPGT	30..526	CDD:278624	149/529 (28%)
Ugt1a1	NP_036815.1	egt	<263..509	CDD:223071	93/251 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.760