DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and Ugt2b35

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_766469.1	Gene:	Ugt2b35 / 243085	MGIID:	3576100	Length:	529	Species:	Mus musculus

Alignment Length:	521	Identity:	144/521 - (27%)
Similarity:	250/521 - (47%)	Gaps:	57/521 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VFPIPSHSHYYHALPYLKKLASLGHEITSVSPF------PLKEPVANIHDIPVPELFDNIEEIVG 88
            |:|: ..||:.:....|.:|...|||:|.:.|.      |...|.......|.....|.:|..:.
Mouse    28 VWPL-EFSHWMNLKIILDELVQRGHEVTVLRPSASIFVDPKYSPGLKFETFPTAFSKDYLETFLT 91

  Fly    89 NLTNRKGTWNEFEY-----------------INQYTLGLVEKVLENDGVRREILQPESLQFDLII 136
            .|.:.   |. ||.                 ::.|:|.|.::.:.|   ::.:.:.:..:||::|
Mouse    92 KLVDE---WT-FEVPRDTCLSYSLLQTLFGKLSDYSLSLCKEAVSN---KQLMTKFQESKFDVLI 149

  Fly   137 VDLWRLDALYG----LAAYFDAPIIGIASYGTDWKIDELVGNVSPLAYLQSPSFNWFDLDTYGGR 197
                 |||:..    :|.....|.:....:...:::::..|     .::..||:....|...||:
Mouse   150 -----LDAMASCGELIAQLLQIPFLYSLRFSPGYQVEKNSG-----GFVLPPSYVPVILSGLGGQ 204

  Fly   198 LGHFVDQ-----SMAWIN-WHWRHEERHEAVYRKYFPKIADKRSLSEITRNFALILVNQHFTMAP 256
            : .|.::     .|.:.: |.....|:....:  |...:....:|.|......:..:..::.:..
Mouse   205 M-TFTERVKNMICMLYFDFWFQTFTEKEWDQF--YSETLGRPTTLIETMGKAEMWFIRSYWDLEF 266

  Fly   257 PRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVRSRNLSKDRRKILIDTF 321
            |.|.:||:..|||:|. :..|.||:::|||:|.:|.|||:.||||:.|  .|::::|...:....
Mouse   267 PHPTLPNVEYVGGLHC-KPAKPLPKEMEDFVQSSGVHGVVVFSLGSMV--SNMTEERANAISWAL 328

  Fly   322 ASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPNVKLFITHGGLQSTVECIHRGVPMLGL 386
            |.:||::||:||....:.:..|..|..|.||.|:|.||..|.|:||||.....|.||.|:||:|:
Mouse   329 AQIPQKVLWRFDGKTPASLGPNTRIYKWLPQNDLLGHPKTKAFVTHGGANGLYEAIHHGIPMIGI 393

  Fly   387 PFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKRTADRYRDQPMNPLD 451
            |.|.:|..|:.|:.|:|..:.||.|.|:..:..:.:.:::...|:.......:..:.||||.||:
Mouse   394 PLFSEQHDNIAHMVAKGTAVALNIRTMSRSDLLNALEEVINNPSYKENVMWLSTIHHDQPMKPLN 458

  Fly   452 TAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLAVWAILSIVVLCAIKLLRAILKSK 516
            ..|:|..:|:|||||.|:|....||.:..||||||:|..|:.|.|...:.|.|.:.:.:..:|..
Mouse   459 RTIFWIEFVMRHKGAKHLRPLAHNLTWYQYHSLDVIGFLLVCVVATAVLPVKCCLFVYQFFVKKA 523

  Fly   517 K 517
            |
Mouse   524 K 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	130/483 (27%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	112/442 (25%)
Ugt2b35	NP_766469.1	egt	8..506	CDD:223071	140/501 (28%)
Ugt2b35	NP_766469.1	UDPGT	24..525	CDD:278624	144/521 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840402
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690