Protein Alignment Ugt35E2 and Ugt1a2

DIOPT Version :10

• Sequence 1: NP_652623.2
• Gene: Ugt35E2 / 53506
• FlyBaseID: FBgn0040255
• Length: 527
• Species: Drosophila melanogaster
• Sequence 2: NP_038729.1
• Gene: Ugt1a2 / 22236
• MGIID: 3576049
• Length: 533
• Species: Mus musculus
• Alignment Length: 567
• Identity: 158/567 - (27%)
• Similarity: 269/567 - (47%)
• Gaps: 104/567 - (18%)

  Fly    11 IVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSP-----------FPL 64
            ::|::..|| ..|||::| |.|:.. |.:......:::|.:.||:...::.           |.|
Mouse    15 LLLLLCALP-WAEGAKVL-VLPMEG-SQWLSMRDVVRELHARGHQTVVLASEVTVHIKGEDFFTL 76

  Fly    65 KEPVANIHDIPV------PELFDNIEE-------IVGNLTNRKGTWNEFE-YINQYTLGLVEKVL 115
            |     .:..|.      .|:..:||:       :...........|.|: |.|.....|..|:|
Mouse    77 K-----TYAFPYTKEEYQQEILSDIEKTFKTQHFVKAFFETTASIRNFFDLYSNSCIALLHNKML 136

  Fly   116 ENDGVRREILQPESLQFDLIIVD-LWRLDALYGLAAYFDAPIIGI---ASYGTDWKIDELVGNVS 176
                    |.|..|..||:|:.| ::...|:  ||.|...|.:.|   .|.|.:::..:.   .:
Mouse   137 --------IQQLNSSFFDVILTDPIFPCGAV--LAKYLQIPAVFILRSLSCGIEYEATQC---PN 188

  Fly   177 PLAYLQSPSFNWFDLDTYGGRLGHFVD-----QSMAWINWHWRHEERHEAVYRKYFPK--IADKR 234
            |.:|:.       :|.|   ||...:|     |:|.:.            :..||..:  |....
Mouse   189 PSSYIP-------NLLT---RLSDHMDFLQRVQNMLYY------------LVLKYICRLSITPYE 231

  Fly   235 SLSE--ITRNFALILVNQH---------FTMAPPRPYVPNIIEVGGMH-VDQQPKALPQDLEDFI 287
            ||:.  :.|..:|:.|..|         |.:..|||.:||::.:||:: |.::|  |.|:.|.::
Mouse   232 SLASELLQREVSLVEVLSHASVWLFRGDFVLDYPRPIMPNMVFIGGINCVTKKP--LSQEFEAYV 294

  Fly   288 QGAGEHGVIYFSLGTNVRSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQ 352
            ..:||||::.||||:.|  ..:.:.:...:.:....:||.:||::.....|::..|.::..|.||
Mouse   295 NASGEHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQ 357

  Fly   353 QDILAHPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDE 417
            .|:|.||..:.||||.|.....|.|..||||:.:|.|.||..|.:.::.:|.|:.||..:||:|:
Mouse   358 NDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADD 422

  Fly   418 FKDTIHQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYH 482
            .::.:..::..||:.....|.:..::|:|:.|||.|::|..||:|||||||:|.|..:|.:..||
Mouse   423 LENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYH 487

  Fly   483 SLDVLGTFLLAVWAILSIVVL----CAIKLLRAILKSKKGNISPKQK 525
            ||||:| ||||:  :|::|.:    ||....:..  ..||.:....|
Mouse   488 SLDVIG-FLLAI--VLTVVFIVFKCCAYGCRKCF--GGKGRVKKSHK 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	MGT	31..443	CDD:273616	113/459 (25%)
		Glycosyltransferase_GTB-type	<247..517	CDD:471961	97/283 (34%)
Ugt1a2	NP_038729.1	UDPGT	28..524	CDD:278624	152/546 (28%)