DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35E2 and ugt-31

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001021756.1	Gene:	ugt-31 / 189771	WormBaseID:	WBGene00021464	Length:	521	Species:	Caenorhabditis elegans

Alignment Length:	552	Identity:	128/552 - (23%)
Similarity:	220/552 - (39%)	Gaps:	95/552 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PVLL---EGARILGVFPIPSHSHYYHALPYLKKLASLGHEIT---SVSPFPLKEPVANIHDIPVP 77
            |:||   |...||...|:...||..........|...||.:|   ||:      .|...|:|.|
Worm     8 PILLVASEPLNILVYSPVFGGSHSKFMGNIADTLTEAGHNVTFLVSVA------DVTRRHEIGV- 65

  Fly    78 ELFDNI-----------------EEIVGNLTNRKGTWNEFEYINQYTLGLVEKVLENDGVRREIL 125
            :|..|:                 :|::..|...:...::|....::.:.:::.........|||.
Worm    66 KLTKNVIIVDKPNFSQDDVEIDMDEVLRPLWTIQNRPSDFATCFEFFIQMMQTTCAEFTSNREIF 130

  Fly   126 QPES-LQFDLIIVDLWRLDALYGLAAYFDAPIIGI-----ASYGTDWK-IDELVGNVSPLAYL-- 181
            :..| .:|.:.|.:...:..|    .||||  :||     ||..|.:: :....|....::|:
Worm   131 KKLSKTEFHVAIAEPVSICGL----GYFDA--LGIKKTILASSTTHYEGVVRNSGEPVDMSYVPV 189

  Fly   182 -------QSPSF----NWFDLDTYGGRLGHFVDQSMA-------WINWHWRHEERHEAVYRKYFP 228
                   :...|    ||.......|.|....||.|:       ....|||
Worm   190 HGAYFDEKMDIFQRYTNWASEHVLAGNLERMFDQEMSEYRKNLVQSTGHWR-------------- 240

  Fly   229 KIADKRSLSEITRNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQ---PKALPQDLEDFIQGA 290
                     ::..:.:|:..|.:..:..|||.:...:.:||:.||.:   .:.||:.:...:: .
Worm   241 ---------DLIPSASLMFTNSNPYLDFPRPVLQKTVGIGGITVDMEQIKSEKLPEKINKLLE-K 295

  Fly   291 GEHGVIYFSLGTNVRSRNLSKDRRKILIDTFASLPQ-RILWKFDADEL--SDVPSNVLISPWFPQ 352
            .|:.:: .|.|:.|:|..:.:..|..::....:.|. ..:||:::|:|  ::...||....|.||
Worm   296 REYNML-ISFGSMVKSSTMPEKWRNSILSAIRNFPNVTFIWKYESDDLRWAENVENVHFLKWIPQ 359

  Fly   353 QDILAHPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDE 417
            ..:|.:|.|..|:|||||.||.|....|.|.:.:|.|.||.||...:...|..|||...|:.:.|
Worm   360 TALLNNPRVSAFLTHGGLGSTNELAFIGKPSIIVPIFGDQGRNAPMLARHGGALVLQKFDLENAE 424

  Fly   418 -FKDTIHQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITY 481
             ..|.|.:::.:||:...||..|:.....|.:|.:..:..|.:|........|....|.|::...
Worm   425 VLIDFIGKIVFDKSYAKNAKTLANLLNASPFSPKELVVKNTEFVGNFGPLTQMDPYIRKLNWFQR 489

  Fly   482 HSLDVLGTFLLAVWAILSIVVLCAIKLLRAIL 513
            ...|:.....|...:|:.|.:....|:.|.||
Worm   490 TFADIYLILFLVYASIIVIPIYVIRKVFRLIL 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	117/511 (23%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	108/467 (23%)
ugt-31	NP_001021756.1	UDPGT	28..518	CDD:278624	118/527 (22%)
ugt-31	NP_001021756.1	Glycosyltransferase_GTB_type	<248..472	CDD:299143	64/225 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810