DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and ugt-8

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_504315.1	Gene:	ugt-8 / 186768	WormBaseID:	WBGene00019234	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	579	Identity:	139/579 - (24%)
Similarity:	230/579 - (39%)	Gaps:	134/579 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LLPVLLEGARILG--------VF-PIPSHSHYYHALPYLKKLASL----GHEITSVSPF--PLKE 66
            ||.:||    :||        :| ||...||    :.::.|:|::    ||.:|...||  .||.
Worm     6 LLSILL----VLGSVSCKNILIFNPIFGLSH----VKFISKMANIIADHGHNVTLFQPFHIALKN 62

  Fly    67 PVANIHD--IPVPELF-DNIEEIV------------GNLTNR---------KGTWNEFEYINQYT 107
            ....|.:  |.:...: |:.:|::            .:|.|.         |....|||  ...|
Worm    63 TEGLIKNKYIEIINYYPDHYDELLKTETATFPAFWDSHLMNNPVLSAFMIPKAIAGEFE--RTAT 125

  Fly   108 LGLVEKVLENDGVRREILQPESLQFDLIIVDLWRLDALYGLAAYFDAPIIGIASYGTDWKIDELV 172
            ..|.:||..:|        .:|..||:||.:.:.|..:| :|...:.|.|.:.|.......:.:.
Worm   126 QLLKDKVALDD--------LKSRNFDVIISETFELTGMY-IAHMLNVPCIPVWSAVRFTIFNNIF 181

  Fly   173 GNVSPLAYLQSP--------SF---------NWF---DLDTYGGRLGHFVDQSMAWINWHWRHEE 217
            |..|.|.|.|.|        .|         |:|   .:|..|.....|:::::.....:|:...
Worm   182 GQPSSLGYSQQPFSKLAPEAGFIDRLNDVYRNFFFTITMDGMGQYQNDFIEKAVGRPLPYWKDLI 246

  Fly   218 RHEAVYRKYFPKIADKRSLSEITRNFALILVNQHFTMAPPRPYVPNIIEVGGM--------HVDQ 274
            :...||               .|.:      |::...|.|.  ...|:.:||.        |||.
Worm   247 KEAPVY---------------FTNS------NEYLDFAVPT--TATIVHIGGFTMDLEKMKHVDP 288

  Fly   275 QPKALPQDLEDFIQGAGEHGVIYFSLGTNVRSRNLSKDRRKILIDTFASLPQ-RILWKFDADEL- 337
            .|....:.||:      ....:..|.|:.:||..:..:.:..:|..|.|||. ..:||::.|::
Worm   289 LPDKYAKILEE------RESTVLISFGSVIRSYQMPDNFKAGIIKMFESLPDVTFIWKYERDDVE 347

  Fly   338 --SDVPSNVLISPWFPQQDILAHPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIK 400
              ..:|.||.:..|.||..:||...||||:|||||.||:|..:.|.|.|.:|.|.||..|...:.
Worm   348 FQKKLPKNVHLKKWVPQHSLLADNRVKLFVTHGGLGSTMEVAYTGKPALMVPIFGDQPENANMLA 412

  Fly   401 AQGIGLVLNYRDMTSDE-FKDTIHQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHK 464
            ..|..:..:..::...| ...||..::....:...|:........||::|....:....:.:..
Worm   413 RHGGAISYDKFELADGEKLAITIRDMVRNPKYNKNAQELLKVLSHQPIDPKLNLMKHLEFAMEF- 476

  Fly   465 GAPHMR---VAGRNLDFITYHSLDVLG----TFLLAVWAILSIVVLCAIKLLRAILKSK 516
              |::|   .|...:..|.::.|||:.    .|:|.|:....|:.|..|:    |:|||
Worm   477 --PNLRSQVPAINQMGLIAHYYLDVIFFLSLIFILTVYLTFKIISLLPIR----IVKSK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	122/532 (23%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	115/485 (24%)
ugt-8	NP_504315.1	UDPGT	30..516	CDD:278624	123/532 (23%)
ugt-8	NP_504315.1	egt	<284..462	CDD:223071	53/183 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810