DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and ugt-65

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_502373.3	Gene:	ugt-65 / 184205	WormBaseID:	WBGene00008583	Length:	509	Species:	Caenorhabditis elegans

Alignment Length:	553	Identity:	136/553 - (24%)
Similarity:	229/553 - (41%)	Gaps:	99/553 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPMSMLVLRLIVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEIT--SVSPFP 63
            ||....::.:|.|:...| .....:|||.:....|.||....:|..::|...||:::  ::|...
Worm     1 MPQYSQLITIIFLLAHFL-TTSNCSRILFLNMFNSKSHALTMMPLAERLFDDGHDVSMYTISANR 64

  Fly    64 LKEPVANIH-----------DIPVPE------LFDNIEEIVGNLTNRKGTWNEFEYINQYTLGLV 111
            ||.|...:.           |...|:      :|.:.|     :|...|.|       .|.:||.
Worm    65 LKIPSKKVKILESLVKGSSTDDAAPDTGGVSRIFWSYE-----MTPYVGAW-------CYEIGLY 117

  Fly   112 EKVLENDGVRREILQPESLQFDLIIVDLWRLDALYGLAAY-----FDAPIIGIASYGTDWKIDEL 171
            ......|....|:|   :..:||.:|| ....:|.|..|.     ....||..|:       .||
Worm   118 YLEEGRDEQLDEVL---ATPYDLAVVD-ETYTSLQGSIALKLKEDHSTKIITFAT-------TEL 171

  Fly   172 VGNVSPL-AYLQSPSF--NWFDL--DTYGGR-----------LGHFVDQSMAWINWHWRHEERHE 220
            :...|.: .|.::|..  |.|.|  :.|.|.           ..:|:||.         :.....
Worm   172 MPVASNMRGYARNPVTVPNTFLLSSEVYEGNRFAFLTRTRRIFEYFIDQI---------YSGPVA 227

  Fly   221 AVYRKYFPKIADKRSLSEITRNF--ALILVNQH---FTMAPPRPYVPNIIEVGGMHVDQQPKALP 280
            ::|.:...|:....|.:: ::.|  :::.||..   |:...||.  .::|.| |.|...... ||
Worm   228 SLYSEASGKLLGLTSATK-SKTFQNSILTVNDFPDTFSFVQPRG--NDLIRV-GEHCYSSAN-LP 287

  Fly   281 QDLEDFIQGAGEHGVIYFSLGTNVRSRNLSKDRRKILIDTFASL-----PQRILWKFDADELSDV 340
            .:..||::.:...|.||.::|:.:   || :|..|..::.|...     ..|::|....: ::..
Worm   288 SEFRDFVEDSMSKGTIYVAMGSYL---NL-EDGPKGTVEAFIEALNYFKDYRVIWSHKGN-VTGA 347

  Fly   341 PSNVLISPWFPQQDILAHPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIG 405
            ..:|....|.||:::|||.....|||||||:|..|.:..|||||.|||:.||.||.......||.
Worm   348 KCHVKSVNWAPQKELLAHEKTVAFITHGGLKSAKEGVCSGVPMLFLPFYGDQPRNAHRFVTNGIA 412

  Fly   406 LVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMR 470
            ..|..:.:||.:.:..:.:||.:.|:.....:....|.|.|::.||...:....|||...:.:.:
Worm   413 EALYKKAITSLDIQQKLEKLLVDPSYKNNVMKVLSYYLDAPISSLDLGAFHISQVLRRTESQYSK 477

  Fly   471 VAGRN--LDFITYHSLDVLGTFLLAVWAILSIV 501
            ...|:  ::.:.|.:||:    .|.:..||.||
Worm   478 FKRRSIFMNHLQYLNLDI----FLVILVILFIV 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	123/509 (24%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	114/463 (25%)
ugt-65	NP_502373.3	egt	<300..505	CDD:223071	62/213 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010