DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35E2 and ugt-46

DIOPT Version :9

Sequence 1:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_508112.1	Gene:	ugt-46 / 180404	WormBaseID:	WBGene00015141	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	535	Identity:	126/535 - (23%)
Similarity:	220/535 - (41%)	Gaps:	69/535 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LRLIVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVS-PFPLKEPVANI 71
            :|||.:::|.........:||...|..|.||.........:||..||::|.:. .|.......|.
Worm     1 MRLIFVLLATFVNAAFSYKILVFSPATSKSHLISNGRLADELARAGHDVTVLELDFLGISQTTNS 65

  Fly    72 HDIPVPELFDNIEEIVGNLTN------------------RKGTWNEFEYINQYTLGLVEKVLEND 118
            ..:....:.|..:|.. |..|                  .||.|   .|.|.|. .|..:.|:.|
Worm    66 VKVAKKRIIDGFQEST-NFKNVLHGFSETVMEEPSFTDEIKGWW---AYQNVYN-DLCAEFLKMD 125

  Fly   119 GVRREILQPESLQFDLIIVDLWRLDALYGLAAYFDAP---IIGIASYGTD-WKIDELVGNVSPLA 179
            .:..|:   ::.:||....:...|.. :|.|...:.|   :|....:... :....|....|.:|
Worm   126 DIFNEL---KNAKFDGFFAEQINLCG-FGYAHALEIPRHFLISSCPFAAPVYDFTGLPMPTSTVA 186

  Fly   180 YLQSPSFNWFDLDTYGGRLGHFVDQSMAWINW---------HWRHEERHEAVYRKYFPKIADKRS 235
            :....|.:    .||..|..:.....:..:.:         |::|:      :.::||      |
Worm   187 FAADLSIS----PTYTERARNLFVAVLTKLEFTLLNNRLQAHFQHK------FGEHFP------S 235

  Fly   236 LSEITRNFALILVNQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSL 300
            |..:|.:..:|.|.....:......:.||:.|||:.||.....:.......: ..|:.|||||||
Worm   236 LYSVTSDVDVIFVATDEIIDISTTTLQNIVHVGGLGVDDDVAEMDNVFASEM-SKGKEGVIYFSL 299

  Fly   301 GTNVRSRNLSKDRRKILIDTFASLPQRILW----KFDAD--ELSDVPSNVLISPWFPQQDILAHP 359
            ||...:..:.....:.::|.....|.....    |:|..  |.:...||..:|.|.||..||.||
Worm   300 GTIANTTKIDSKVMRTVLDIVKKFPDYHFVIRADKYDLSTREYAKSVSNAFVSDWLPQPAILHHP 364

  Fly   360 NVKLFITHGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTS--DEFKDTI 422
            .:||||||.|..|.||....|||::.:||.:||..|...::.:|.|:..:.:.:.:  :|.:..|
Worm   365 RLKLFITHSGYNSIVEAARAGVPLINIPFMFDQNLNSRAVEKKGWGIRRHKKQLLTEPEEIEKAI 429

  Fly   423 HQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVL 487
            .:::..|.:.:||:|..|..:.:|::.....|..|.:.:::.|...::...|.....||::|||:
Worm   430 SEIIHNKKYSLKAQRIRDLIKSKPLSSSQLLIKTTEWAIKNHGLDEIKFESRGQTTWTYYNLDVI 494

  Fly   488 GTFLLAVWAILSIVV 502
               :...|..:|:|:
Worm   495 ---IPVFWLSISLVI 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	114/497 (23%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	108/453 (24%)
ugt-46	NP_508112.1	UDPGT	19..527	CDD:278624	122/517 (24%)
ugt-46	NP_508112.1	egt	<213..503	CDD:223071	79/305 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810